190515-65-2

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-[(methylsulfonyl)amino]-, methyl ester, trans-
• CAS NO: 190515-65-2
• Molecular Formula: C9H17NO4S
• Molecular Weight: 235.304
• Mol File: 190515-65-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-[(methylsulfonyl)amino]-, methyl ester, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-[(methylsulfonyl)amino]-, methyl ester, trans-(190515-65-2)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-[(methylsulfonyl)amino]-, methyl ester, trans-(190515-65-2)

Safety Data

• Hazardous Substances Data: 190515-65-2(Hazardous Substances Data)

Upstream product

• 61367-07-5 trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride 
• 7143-01-3 Methanesulfonic anhydride 
• 62456-15-9 methyl trans-4-amino-cyclohexanecarboxylate 
• 124-63-0 methanesulfonyl chloride 
• 1776-53-0 trans-4-aminocyclohexanecarboxylic acid 

Downstream Products

• 190515-68-5 Methyl trans-4-(N-tert-Butoxycarbonylmethyl-N-methanesulphonylamino)cyclohexanecarboxylate 

Relevant articles and documents

INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation

5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imidazole, (b) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (c) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (d) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (e) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (f) 5-??trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (g) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (h) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, and (i) 4-??trans-4-carboxycyclohexyl!aminocarbonyl!-1-?2-(4-piperidyl)ethyl!imidazole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.