19063-58-2Relevant articles and documents
Water soluble and fluorescent copolymers as highly sensitive and selective fluorescent chemosensors for the detection of cyanide anions in biological media
Isaad, Jalal,Malek, Fouad,El Achari, Ahmida
, p. 22168 - 22175 (2013)
We report a simple colorimetric method based on a water soluble polymer (WSP) for the sensitive and selective detection of cyanide in a biological solution. The WSPs were prepared from a radical polymerization of a methacrylate with a cyanide chemosensor moiety based on a coumarin-dicyano-vinyl derivative motif, and the polymer was then rendered water soluble by copolymerizing this hydrophobic monomer with other glyco-conjugated methacrylate derivatives. The lowest concentration for the quantification of cyanide ions was 0.05 μM, and the polymer exhibited nearly no calorimetric response to the presence of other common anions. Therefore, the chemical incorporation of some carbohydrates, as lactose or its usual monosaccharide moieties (glucose, lactose), represents a new method for the implementation of polymers for the detection of cyanide anions in water, exhibiting both good selectivity and efficiency. The Royal Society of Chemistry 2013.
Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological ph: Biological implications
Smulik, Renata,Debski, Dawid,Zielonka, Jacek,Michalowski, Bartosz,Adamus, Jan,Marcinek, Andrzej,Kalyanaraman, Balaraman,Sikora, Adam
, p. 35570 - 35581 (2014)
Nitroxyl (HNO), the protonated one-electron reduction product of NO, remains an enigmatic reactive nitrogen species. Its chemical reactivity and biological activity are still not completely understood. HNO donors show biological effects different from NO donors. Although HNO reactivity with molecular oxygen is described in the literature, the product of this reaction has not yet been unambiguously identified. Here we report that the decomposition of HNO donors under aerobic conditions in aqueous solutions at physiological pH leads to the formation of peroxynitrite (ONOO-) as a major intermediate. We have specifically detected and quantified ONOO- with the aid of boronate probes, e.g. coumarin-7-boronic acid or 4-boronobenzyl derivative of fluorescein methyl ester. In addition to the major phenolic products, peroxynitrite-specific minor products of oxidation of boronate probes were detected under these conditions. Using the competition kinetics method and a set of HNO scavengers, the value of the second order rate constant of the HNO reaction with oxygen (k = 1.8 × 104 M-1 S-1) was determined. The rate constant (k = 2 × 104 M-1 S-1) was also determined using kinetic simulations. The kinetic parameters of the reactions of HNO with selected thiols, including cysteine, dithiothreitol, N-acetylcysteine, captopril, bovine and human serum albumins, and hydrogen sulfide, are reported. Biological and cardiovascular implications of nitroxyl reactions are discussed.
Ytterbium triflate promoted coupling of phenols and propiolic acids: Synthesis of coumarins
Fiorito, Serena,Epifano, Francesco,Taddeo, Vito A.,Genovese, Salvatore
supporting information, p. 2939 - 2942 (2016/06/14)
Coumarins are a well-known class of natural occurring and semi-synthetic products with reported important and effective pharmacological activities. In this Letter an improved method for the chemical synthesis of such compounds is described. Coumarins have been obtained in good to excellent yields under microwave irradiation and solvent-free conditions in a short time from differently substituted phenols and propiolic acids used as starting materials in the presence of Yb(OTf)3 hydrate 10% mol as the catalyst.
