19064-65-4

Basic information

• Product Name: 3-METHOXYPYRIDAZINE
• Synonyms: 3-METHOXYPYRIDAZINE;3-Methoxy-1,2-diazine;3-MethoxypyridaziIne
• CAS NO: 19064-65-4
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Mol File: 19064-65-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 244℃
• Flash Point: 89℃
• Appearance: A white powder
• Density: 1.102
• Vapor Pressure: 0.0478mmHg at 25°C
• Refractive Index: 1.5140 to 1.5180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.21±0.10(Predicted)
• CAS DataBase Reference: 3-METHOXYPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYPYRIDAZINE(19064-65-4)
• EPA Substance Registry System: 3-METHOXYPYRIDAZINE(19064-65-4)

Safety Data

• Hazardous Substances Data: 19064-65-4(Hazardous Substances Data)

Usage

General Description

3-Methoxypyridazine is a chemical compound with the molecular formula C5H6N2O that is used in the pharmaceutical and agrochemical industries. It is a heterocyclic compound that contains a pyridazine ring with a methoxy group attached to it. 3-Methoxypyridazine has potential applications as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a flavoring agent in the food industry, providing a nutty, roasted, or coffee-like aroma. The compound is a colorless to pale yellow liquid with a strong odor and is soluble in most organic solvents. It is important to handle 3-Methoxypyridazine with care as it can be harmful if it comes into contact with the skin or if it is ingested or inhaled.

InChI:InChI=1/C5H6N2O/c1-8-5-3-2-4-6-7-5/h2-4H,1H3

Upstream product

• 1120-95-2 3-chloropyridazine 
• 67-56-1 methanol 
• 141-30-0 3,6-dichlorpyridazine 
• 124-41-4 sodium methylate 
• 1722-10-7 3-chloro-6-methoxypyridazine 

Downstream Products

• 551920-20-8 1-[6-(methoxy)pyrazolo[1,5-b]pyridazin-3-yl]ethanone 
• 1263279-79-3 methyl 6-methoxypyrazolo[1,5-b]pyridazine-3-carboxylate 
• 1434271-72-3 (S)-3-(4-bromophenyl)-1-(3-methoxypyridazin-4-yl)-3-o-tolylpropan-1-one 
• 1093951-68-8 3-methoxy-4-(tributylstannyl)pyridazine 
• 1722-10-7 3-chloro-6-methoxypyridazine 
• 89179-63-5 3-Methoxy-4-amino-pyridazin 
• 172879-48-0 3-Methoxy-4-(p-tolylsulfonylmethyl)pyridazinium 1-dicyanomethylide 
• 172879-45-7 3-Methoxy-4-(phenylsulfonylmethyl)pyridazinium 1-dicyanomethylide 
• 748141-84-6 [4-(6-methoxy-pyrazolo[1,5-b]pyridazin-3-yl)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine 

Relevant articles and documents

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IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalisation of the metathesis products is possible both prior to and after aromatisation. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds.