19073-16-6

Upstream product

• 99-92-3 p-aminobenzophenone 
• 107-21-1 ethylene glycol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 36881-02-4 2-(4-chlorophenyl)-2-methyl-1,3-dioxolane 
• 1296794-13-2 4-methyl-N-(4-(2-methyl-1,3-dioxolan-2-yl)phenyl)benzenesulfonamide 
• 19073-15-5 2-(4-nitrophenyl)-2-methyl-1,3-dioxolane 

Downstream Products

• 1198463-84-1 (Z)-3-[4-(2-methyl-1,3-dioxolan-2-yl)phenylamino]-1,3-diphenylprop-2-en-1-one 
• 13329-40-3 4-Iodoacetophenone 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 99-92-3 p-aminobenzophenone 
• 99-90-1 para-bromoacetophenone 
• 99-91-2 para-chloroacetophenone 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Palladium-catalyzed amination of aryl chlorides and bromides with ammonium salts

We report the palladium-catalyzed coupling of aryl halides with ammonia and gaseous amines as their ammonium salts. The coupling of aryl chlorides and ortho-substituted aryl bromides with ammonium sulfate forms anilines with higher selectivity for the primary arylamine over the diarylamine than couplings with ammonia in dioxane. The resting state for the reactions of aryl chlorides is different from the resting state for the reactions of aryl bromides, and this change in resting states is proposed to account for a difference in selectivities for reactions of the two haloarenes.

Ti(O-i-Pr)4/Me3SiCl/Mg-mediated reductive cleavage of sulfonamides and sulfonates to amines and alcohols

A low-valent titanium generated in situ from Ti(O-i-Pr)4, Me3SiCl, and Mg powder in THF reacted with aryl- and alkyl-sulfonamides of aryl and alkyl amines in a reductive N-S/S-O/S-C bond cleaving pathway to provide the corresponding amines and hydrocarbons (and thiols) derived from the sulfonyl moiety. The reagent could also cleave sulfonates to the corresponding alcohols.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

A mild procedure for the clay catalyzed selective removal of the tert- butoxycarbonyl protecting group from aromatic amines

The application of solid acidic catalysts for the selective removal of N-Boc protection is presented in this report. Montmorillonite K10 was found to be an effective catalyst in removing aromatic N-Boc groups while leaving aliphatic N-Boc amines untouched.