191231-58-0

Basic information

• Product Name: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE
• Synonyms: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE;(S)-N-methyl-1-(1-Bocpyrrolidin-2-yl)methanamine;(S)-tert-butyl 2-((methylamino)methyl)pyrrolidine-1-carboxylate;tert-butyl (2S)-2-[(MethylaMino)Methyl]pyrrolidine-1-carboxylate;(S)-2-[(Methylamino)methyl]-1-pyrrolidinecarboxylic acid tert-butyl ester;(S)-1-Boc-2-(N-methylaminomethyl)-pyrrolidine
• CAS NO: 191231-58-0
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Mol File: 191231-58-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.004
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.17±0.10(Predicted)
• CAS DataBase Reference: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE(191231-58-0)
• EPA Substance Registry System: (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE(191231-58-0)

Safety Data

• Hazardous Substances Data: 191231-58-0(Hazardous Substances Data)

Usage

General Description

(S)-1-BOC-2-(methylaminomethyl)-pyrrolidine is a compound with the chemical formula C12H24N2O2. It is a chiral compound, with the (S)-enantiomer being the biologically active form. (S)-1-BOC-2-(METHYLAMINOMETHYL)-PYRROLIDINE is often used in organic synthesis as a building block for the preparation of other pharmaceutical and agrochemical compounds. The BOC (tert-butoxycarbonyl) group on the nitrogen atom provides protection, allowing for selective reactions at other functional groups in the molecule. It is also used as a chiral auxiliary in asymmetric synthesis to control the stereochemistry of reactions. Overall, (S)-1-BOC-2-(methylaminomethyl)-pyrrolidine is a versatile compound with applications in various fields of organic chemistry.

Upstream product

• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 627-37-2 N-methyl-N-allylamine 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 168049-26-1 tert-butyl (2S)-2-(azidomethyl)-1-pyrrolidinecarboxylate 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 119020-01-8 (S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 475106-27-5 C₁₃H₂₁F₃N₂O₃ 
• 168049-31-8 (S)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists

Nonpeptide sst2 agonists can provide a new treatment option for patients with acromegaly, carcinoid tumors, and neuroendocrine tumors. Our medicinal chemistry efforts have led to the discovery of novel 3,4-dihydroquinazoline-4-carboxamides as sst2 agonist

SOMATOSTATIN MODULATORS AND USES THEREOF

Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or diso

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: Improvement of potency in vitro and in vivo

We have increased the potency of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors with two strategies. One is to enhance the activity in cell-based assay by adjusting the polarity of molecules to improve permeability. Another is to increase the affinity for IKKβ by the introduction of additional substituents based on the hypothesis derived from an interaction model study. These improved compounds showed inhibitory activity of TNFα production in mice.