19141-39-0

Basic information

• Product Name: (R)-1-Chloro-2-propanol
• Synonyms: 2-PROPANOL, 1-CHLORO-, (2R)-;(R)-1-CHLORO-2-PROPANOL;(R)-1-CHLORO-2-PROPANOL 98+%;(2R)-1-Chloro-2-propanol;(R)-1-Chloro-2-propa;(R)-1-Chloropropan-2-ol;(2R)-1-chloropropan-2-ol
• CAS NO: 19141-39-0
• Molecular Formula: C₃H₇ClO
• Molecular Weight: 94.54
• Product Categories: API intermediates;Chiral Compound
• Mol File: 19141-39-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 126.499 °C at 760 mmHg
• Flash Point: 54.541 °C
• Appearance: /
• Density: 1.083 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.09±0.20(Predicted)
• CAS DataBase Reference: (R)-1-Chloro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Chloro-2-propanol(19141-39-0)
• EPA Substance Registry System: (R)-1-Chloro-2-propanol(19141-39-0)

Safety Data

• RIDADR: 2611
• PackingGroup: Ⅱ
• Hazardous Substances Data: 19141-39-0(Hazardous Substances Data)

Usage

General Description

"(R)-1-Chloro-2-propanol" is an organic compound comprised of carbon, hydrogen, chlorine, and oxygen. It is a type of chlorohydrin and an isomer of 2-chloropropanol. The "(R)" denotes the configuration of the chiral center of the compound, meaning that its structure is arranged in a certain way. This chemical is used in the production of various goods within the chemical industry. However, due to its toxic and corrosive nature, it requires careful handling and appropriate safety measures during use.

Upstream product

• 15448-47-2 (R)-propylene oxide 
• 36220-92-5 1-chloro-2-benzoyloxypropane 
• 67-56-1 methanol 
• 16088-62-3 (S)-Propylene oxide 
• 108-05-4 vinyl acetate 
• 127-00-4 1-Chloro-2-propanol 
• 75-56-9 methyloxirane 
• 187737-37-7 propene 
• 78-95-5 chloroacetone 

Downstream Products

• 1552286-61-9 C₁₈H₁₆ClN₅O₂ 
• 1429397-14-7 (R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxypropyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea 
• 1268474-80-1 (R)-methyl 2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoate 

Relevant articles and documents

Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).

A new dinuclear chiral salen complexes for asymmetric ring opening and closing reactions: Synthesis of valuable chiral intermediates

A new dinuclear chiral Co(salen) complexes bearing group 13 metals have been synthesized and characterized. The easily prepared complexes exhibited very high catalytic reactivity and enantioselectivity for the asymmetric ring opening of epoxides with H2O, chloride ions and carboxylic acids and consequently provide enantiomerically enriched terminal epoxides (>99% ee). It also catalyzes the asymmetric cyclization of ring opened product, to prepare optically pure terminal epoxides in one step. The homogeneous dinuclear chiral Co(salen) have been covalently immobilized on MCM-41. The potential benefits of heterogenization include facilitation of catalyst separation and recyclability requiring very simple techniques. The system described is very efficient.

The effect of catechin derivatives on the enantioselectivity of lipase-catalyzed hydrolyses of alkynol benzoate esters

Polyphenols, such as (+)-catechin and pyrogallol could be used to enhance stereochemical control in the lipase-catalyzed hydrolysis of alkynol benzoate esters, leading to increased enantioselectivities in the kinetic resolution of alkynols with lipase Amano AH.