19158-31-7

Basic information

• Product Name: Morpholine, 4-[(phenylmethyl)sulfonyl]-
• CAS NO: 19158-31-7
• Molecular Formula: C11H15NO3S
• Molecular Weight: 241.311
• Mol File: 19158-31-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(phenylmethyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(phenylmethyl)sulfonyl]-(19158-31-7)
• EPA Substance Registry System: Morpholine, 4-[(phenylmethyl)sulfonyl]-(19158-31-7)

Safety Data

• Hazardous Substances Data: 19158-31-7(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 76625-87-1 bis(phenylmethyl) α-disulfone 
• 1939-99-7 benzenesulfonyl chloride 
• 1697-34-3 4-methanesulfonylmorpholine 
• 108-86-1 bromobenzene 
• 16601-40-4 S-benzyl phenyl-methanethiosulfonate 
• 51793-64-7 sodium α-toluenesulfinate 
• 108-90-7 chlorobenzene 

Downstream Products

• 88534-26-3 N-<α-(trimethylsilyl)benzylsulfonyl>morpholine 
• 71376-55-1 4-([1-phenylbut-3-en-1-yl]sulfonyl)morpholine 
• 22456-73-1 4-(nitro-phenyl-methanesulfonyl)-morpholine 
• 71376-63-1 4-(dichloro-phenyl-methanesulfonyl)-morpholine 
• 94801-87-3 4-(3-diethylamino-1-phenyl-propane-1-sulfonyl)-morpholine 
• 71376-54-0 4-(1-phenyl-butane-1-sulfonyl)-morpholine 
• 93950-78-8 4-(1,2-diphenyl-ethanesulfonyl)-morpholine 
• 94907-49-0 4-(4,4-dimethyl-1-phenyl-pentane-1-sulfonyl)-morpholine 
• 71376-53-9 4-(1-phenyl-propane-1-sulfonyl)-morpholine 
• 71376-64-2 α-chlorobenzyl 4-morpholinyl sulfone 
• 71376-62-0 4-(1-chloro-1-phenyl-propane-1-sulfonyl)-morpholine 
• 93019-85-3 4-(phenyl-pyridin-2-yl-methanesulfonyl)-morpholine 
• 88534-33-2 phenyl(morpholinosulfonyl)sulfine 

Relevant articles and documents

Sulfinates from Amines: A Radical Approach to Alkyl Sulfonyl Derivatives via Donor-Acceptor Activation of Pyridinium Salts

Synthetically versatile alkyl sulfinates can be prepared from readily available amines, using Katritzky pyridinium salt intermediates. In a catalyst-free procedure, primary, secondary, and benzylic alkyl radicals are generated by photoinduced or thermally induced single-electron transfer (SET) from an electron donor-acceptor (EDA) complex, and trapped by SO2 to generate sulfonyl radicals. Hydrogen atom transfer (HAT) from Hantzsch ester gives alkyl sulfinate products, which are used to prepare a selection of medicinal chemistry relevant sulfonyl-containing motifs.

Benzothiazole Sulfinate: A Sulfinic Acid Transfer Reagent under Oxidation-Free Conditions

Sulfinic acids are commonly encountered intermediates found in natural product synthesis and medicinal chemistry. However, because of high reactivity, instability, and harsh reaction conditions, they are difficult to synthesize. Herein we have developed an oxidation-free method to produce sulfinic acids and sulfinate salts using 2-sulfinyl benzothiazole (BTS). We have also demonstrated the synthetic usefulness by developing one-pot syntheses of sulfones and sulfonamides.

Palladium-catalyzed benzylic direct arylation of benzyl sulfones with aryl halides

An effective palladium catalyst system for the direct arylation of benzyl sulfones with aryl halides has been developed. The catalytic reaction provides a facile route to diarylmethyl sulfones. The products can be transformed further via desulfonylative functionalization mediated by aluminum compounds.