1697-34-3

Usage

Uses

Used in Organic Synthesis:
4-Methanesulfonyl morpholine is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of a wide range of organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-Methanesulfonyl morpholine is used as an intermediate in the production of various drugs, playing a crucial role in the synthesis of medicinal compounds.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 4-Methanesulfonyl morpholine is utilized as an intermediate for the synthesis of different agrochemicals, aiding in the development of products for agricultural applications.
Used in the Synthesis of Sulfonyl Chlorides:
4-Methanesulfonyl morpholine is used as a reagent in the synthesis of sulfonyl chlorides, which are important compounds in organic chemistry and have various applications in the production of pharmaceuticals and agrochemicals.
Used in the Synthesis of Sulfonamides:
Additionally, 4-Methanesulfonyl morpholine is employed in the synthesis of sulfonamides, a class of antimicrobial agents that are significant in the field of medicine for treating bacterial infections.

Upstream product

• 110-91-8 morpholine 
• 124-63-0 methanesulfonyl chloride 
• 10383-49-0 methyl α-disulfone 
• 80284-02-2 N-nitromethanesulfonimide 
• 4837-30-3 1-(methylthio)morpholine 
• 20277-69-4 sodium methansulfinate 
• 13368-42-8 4-(trimethylsilyl)morpholine 
• 558-25-8 methyl fluorosulfonate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 110417-55-5 N-[(2-Phenyloxo-2-ethane)sulphonyl]morpholine 
• 130179-00-9 (morpholinosulphonylmethyl)-(4-fluorophenyl)-ketone 
• 130178-98-2 1-(4-Chloro-phenyl)-2-(morpholine-4-sulfonyl)-ethanone 
• 130179-03-2 1-(4-Methoxy-phenyl)-2-(morpholine-4-sulfonyl)-ethanone 
• 130179-02-1 1-(4-tert-Butyl-phenyl)-2-(morpholine-4-sulfonyl)-ethanone 
• 130179-05-4 1-(4-Dimethylamino-phenyl)-2-(morpholine-4-sulfonyl)-ethanone 
• 1026484-23-0 1-(4-morpholinylsulfonyl)-3-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfanyl)acetone 
• 202286-54-2 9-isopropyl-7,12-dimethyl-3-(morpholinosulfonyl)benzo[a]heptalene-2,4-diol 
• 19158-31-7 4-(phenylmethane)sulfonylmorpholine 
• 130178-85-7 4-[2-(4-Trifluoromethyl-phenyl)-ethynesulfonyl]-morpholine 
• 130178-88-0 4-[2-(4-Nitro-phenyl)-ethynesulfonyl]-morpholine 
• 130178-83-5 4-[2-(2,4-Dichloro-phenyl)-ethynesulfonyl]-morpholine 
• 130178-89-1 Dimethyl-[4-(morpholine-4-sulfonylethynyl)-phenyl]-amine 
• 130178-86-8 4-[2-(4-tert-Butyl-phenyl)-ethynesulfonyl]-morpholine 

Relevant academic research and scientific papers

Electrosynthesis of sulfonamides from DMSO and amines under mild conditions

With DMSO as the solvent and the precursor of a -SO2Me unit at room temperature, a novel electrochemical oxidization and amination of DMSO with amines was developed for the synthesis of sulfonamides. Our investigations reveal that this transformation may involve a radical process and an electrochemical oxidization of DMSO.

PTAB mediated open air synthesis of sulfonamides, thiosulfonates and symmetrical disulfanes

A facile methodology has been described which has successfully simplified the generation of sulfonamides, thiosulfonates and symmetric disulfanes. This “trio” of reactions occur in an open air metal free atmosphere and has also been scaled up to grams making it suitable for commercialization. The reactions also have been successfully carried out with asymmetric variants, thus contributing to the chiral pool. The user friendly “trio” enables easy generation of these versatile sulfur analogues and the reaction condition employed depict an economic outline.

Process for the Synthesis of Sulfones and Sulfonamides

A one pot single step process is described for the synthesis of a compound, including a labeled compound, containing a sulfonyl functional group comprising the step of mixing together a silane, an SO2 source, an electrophilic compound, an activ

Selective caspase inhibitors and uses thereof

The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).

Copper-catalyzed electrophilic amination of sodium sulfinates at room temperature

By using O-benzoyl hydroxylamines as amine sources, the first convenient copper-catalyzed electrophilic amination of sodium sulfinates has been realized. Even with 2 mol% catalyst loading, the protocol provided an efficient and straightforward synthesis of a broad range of functional sulfonamides under ambient reaction conditions without an additional base and ligand. Based on the control experiments, a plausible mechanism was proposed.

Iodine-catalyzed oxidative amination of sodium sulfinates: A convenient approach to the synthesis of sulfonamides under mild conditions

The iodine-catalyzed oxidative amination of sodium sulfinates in the presence of sodium percarbonate as the oxidant has been developed. The reaction shows good substrate scope and tolerates a wide range of functionalities in both amine and sodium sulfinate substrates. Aliphatic amines, heteroaromatic amines and hydrochloride salts of amines canbe employed as the amine sources in this transformation. Mechanistic studies indicated that a radical pathway might be involved in the reaction process. This transition-metalfree protocol offers an alternative and convenient approach for a preparation of a series of sulfonamides in moderate to good yields under mild conditions.

Metal-free oxidative coupling of amines with sodium sulfinates: A mild access to sulfonamides

A practical and mild procedure for the preparation of sulfonamides through TBAI-catalyzed oxidative coupling of amines with sodium sulfinates using TBHP as an oxidant was presented. A variety of amines and sodium sulfinates could go through the transformation, without impacting the hydroxyl group. This journal is

Preparation of sulfonamides from N-silylamines

Sulfonamides have been prepared in high yields by the reactions of N-silylamines with sulfonyl chlorides and fluorides. In a competition experiment, the sulfonyl chlorides were found to be far more reactive than sulfonyl fluorides. The chemistry may be used to prepare aliphatic, aromatic, tertiary, secondary, and primary sulfonamides. It may also be done in the absence of solvent and the byproduct trimethylsilyl chloride recovered in good yield. Primary sulfonamides were synthesized from the sulfonyl chloride with aminotriphenyl silane (Ph3SiNH2), a conversion demonstrated with the synthesis of the carbonic anhydrase inhibitor, acetazolamide.

Copper-catalyzed sulfonamides formation from sodium sulfinates and amines

A new and convenient method for the construction of sulfonamides via a copper-catalyzed oxidative coupling between sodium sulfinates and amines with 1 atm O2 or DMSO as the oxidant was described. This method provides efficient and robust synthesis of functional sulfonamides in good yields and excellent chemoselectivity. And detailed mechanistic studies showed that this transformation may go through a single electron transfer (SET) pathway.

Leishmanicidal potential of N-substituted morpholine derivatives: Synthesis and structure-activity relationships

A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All of the synthesised compounds 2-20 were screened for their leishmanicidal effects using amphotericin B (IC50 = 0.24 μg L-1) and pentamidine (IC50 = 2.56 μg mL-1) as standards and a structure-activity relationship (SAR) study was established. The compounds 2 (IC50 = 48 μg mL-1), 3 (IC50 = 30.0 μg mL-1), 10 (IC50 = 41.0 μg mL-1), 15 (IC50 = 33.0 μg mL-1), 16 (IC50 = 35.0 μg mL-1) and 20 (IC50 = 47.0 μg mL-1) showed weak leishmanicidal activities.