19165-97-0Relevant academic research and scientific papers
Mechanochemical ritter reaction: A rapid approach to functionalized amides at room temperature
Dokli, Irena,Gredi?ak, Matija
, p. 2727 - 2732 (2015)
A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using a Br?nsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols. Gentle Ritter: A fast and efficient mechanochemical Ritter reaction under mild conditions is described. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using sulfuric acid as catalyst.
