636-12-4Relevant academic research and scientific papers
Design, synthesis and molluscicidal activity of new phosphorus compounds bearing fluorine substituted 1,2,4-triazolo[3,2-c][1,2,4]triazine derivatives
Abdel-Rahman, Reda M.,Alharbi, Abdulrahman S.,Alshammari, Nawaa A.,Adnan, Yousuf O.
, p. 184 - 190 (2020/02/29)
Novel phosphorus compounds bearing fluorine substituted 1,2,4-triazolo[3,2-c][1,2,4]triazine derivatives have been synthesized, starting from ring closure reactions of 3-hydrazino-4-(4`-fluorophenyl)-5-(prydin-4`-yl)-1,2,4-trizole (4) with 1,2-bioxygen co
Synthesis, anti-inflammatory, antimicrobial potential and molecular docking studies of 4,5-disubstituted-1,2,4-triazole thioacetate derivatives
Arif, Muhammad Nouman,Nadeem, Humaira,Paracha, Rehan Zafar,Khan, Arif-Ullah,Imran, Muhammad,Ali, Fawad
, p. 734 - 745 (2019/08/26)
Background: In the present study synthesis and biological assessment of nine new ethyl [(4,5-disubstituted-4H-1,2,4-triazol-3-yl)sulfanyl]acetate derivatives 2(a-i) is performed. Methods: The title compounds were characterized by their analytical and spec
Synthesis and antimicrobial activity of some new 1,2,4-trizoles
Jain, Rakesh Kumar,Mishra, Vikash Kumar,Kashaw, Varsha
, p. 1317 - 1322 (2017/05/02)
A series of 1,2,4-triazole derivatives were synthesized using appropriate synthetic route and structures were confirmed by IR,1H NMR and elemental analysis. All the synthesized compounds (6a-6h and 7a-7h) were evaluated for antimicrobial activity by determining their minimum inhibitory concentrations (MICs) against a panel of Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed significant antimicrobial activity against Gram-positive bacteria viz. S. aureus, B. subtilis, Gram-negative bacteria viz. E. coli, P. aerugenosa and fungi viz. C. albicans, A. niger. Some of the compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. Compounds 7g, 6g, 6a exhibited good MICs against Gram-positive bacteria and 7f showed better MICs against Gram-negative bacteria compared to reference norfloxacin. Compounds 7f and 7d exhibited MICs which is equipotent to the reference drug ketoconazole.
New and efficient synthesis of N-(4-substituted phenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amines
Bhat,Ghabbour,Kumar,Fun
, p. 8483 - 8487 (2015/12/31)
The reaction of 2-isonicotinoyl-N-arylhydrazinecarbothioamide (2a-c) with chloroacetic acid in presence of anhydrous sodium acetate in absolute ethanol yields, in each case, a single product. The single crystal X-ray analysis confirmed the structure of these products as N-(4- aryl)-5-(pyridine-4-yl)-1,3,4-oxadiazol-2-amines (4a-c).
Synthesis, structure and alkylation of 4-(4-Fluoro phenyl)-5-(isomeric pyridyl)-1,2,4-triazole-3-thiole
Shahabi, Soulmaz Seyyed,Gharibi, Mahtab
experimental part, p. 2422 - 2424 (2012/08/27)
New 3,5-disubstituted-1,2,4-triazole and their derivatives 3(a-c) were synthesized in excellent yield by the intra molecular cyclization of 1,4- disubstituted thiosemicarbazides 2(a-c) with sodium hydroxide. Their further alkylation with methyl iodide in
Selective synthesis and characterization of substituted 1,3,4-thiadiazole/oxadiazole and 1,2,4-triazole heterocyclic rings
Shahabi, Soulmaz Seyyed,Gharibi, Mahtab
experimental part, p. 2975 - 2979 (2012/08/29)
A new series of 5-(isomeric pyridyl)-1,3,4-thiadiazole 3(a-c)/oxadiazole 6(a-c) and 4-(4-fluoro phenyl)-5-(isomeric pyridyl)-1,2,4-triazole- 3-thiol 4(a-c)/3-methyl thiol 5(a-c) derivatives were synthesized in excellent yield and under different condition
1,3,4-Thiadiazole derivatives. Synthesis, structure elucidation, and structure-antituberculosis activity relationship investigation
Oru?, El?in E.,Rollas, Sevim,Kandemirli, Fatma,Shvets, Nathaly,Dimoglo, Anatholy S.
, p. 6760 - 6767 (2007/10/03)
A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, the compounds structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-(4-fluorophenyl) -1,3,4-thiadiazole 22 showed the highest inhibitory activity. The relationships between the structures of compounds and their antituberculosis activity were investigated by the Electronic-Topological Method (ETM) and feed forward neural networks (FFNNs) trained with the back-propagation algorithm. As a result of the approach, a system of pharmacophores and anti-pharmacophores has been found that effectively separates compounds of the examination set into groups of active and inactive compounds. The system can be applied to the screening and design of new active compounds possessing skeletons similar to those used in the present study.
Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities.
Guelerman,Dogan,Rollas,Johansson,Celik
, p. 953 - 958 (2007/10/03)
5-(4-Pyridinyl)-4-substituted-2.4-dihydro-3H-1,2,4-triazole-3-thiones and 5-(4-pyridinyl)-4-substituted-3-(benzoylmethyl)thio-4H-1,2,4-triazoles were synthesized. The structures of original nine compounds were confirmed by IR, 'H NMR, mass spectral methods and elemental analysis. The antibacterial, antifungal and antimycobacterial activities, together with those of known intermediate 1,4-disubstituted thiosemicarbazides, were reported.
