192062-06-9Relevant academic research and scientific papers
Synthesis of 2-alkoxyestradiols
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, (2008/06/13)
Disclosed is a method of preparing a compound represented by the following structural formula: The method comprises reacting bromine (Br2) and an aliphatic organic acid with a compound represented by the following structural formula: R1 and R2 are each independently a hydroxyl protecting group.
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth
Cushman, Mark,He, Hu-Ming,Katzenellenbogen, John A.,Varma, Ravi K.,Hamel, Ernest,Lin, Chii M.,Ram, Siya,Sachdeva, Yesh P.
, p. 2323 - 2334 (2007/10/03)
A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubulin polymerization inhibitor. The compounds were evaluated as inhibitors of tubulin polymeriza
