69455-04-5Relevant academic research and scientific papers
Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth
Cushman, Mark,He, Hu-Ming,Katzenellenbogen, John A.,Varma, Ravi K.,Hamel, Ernest,Lin, Chii M.,Ram, Siya,Sachdeva, Yesh P.
, p. 2323 - 2334 (1997)
A new series of estradiol analogs was synthesized in an attempt to improve on the anticancer activity of 2-methoxyestradiol, a naturally occurring mammalian tubulin polymerization inhibitor. The compounds were evaluated as inhibitors of tubulin polymeriza
A chemometric approach to map reaction media chemoselectivity: Example of selective debenzylation
Bensel, Nicolas,Klaer, Daniel,Catala, Cedric,Schneckenburger, Patrick,Hoonakker, Frank,Goncalves, Sylvie,Wagner, Alain
supporting information; experimental part, p. 2261 - 2264 (2010/07/10)
A chemometric process consisting in measuring the reactivity of a set of substrates under standardized and complementary reaction conditions was run to evaluate the possibility of building a coherent database that would give a general overview of the sele
17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS
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Page/Page column 70-71, (2008/12/08)
Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Combinations with other active pharmaceutical agents are also disclosed.
Estradiol conjugates and uses thereof
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Page/Page column 11; 13, (2010/11/08)
A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.
Synthesis and evaluation of B-, C-, and D-ring-substituted estradiol carboxylic acid esters as locally active estrogens
Labaree, David C.,Zhang, Jing-Xin,Harris, Heather A.,O'Connor, Craig,Reynolds, Toni Y.,Hochberg, Richard B.
, p. 1886 - 1904 (2007/10/03)
We have synthesized derivatives of estradiol that are structurally modified to serve as "soft" estrogens and act within a geographically limited area of the body; estrogens without systemic action. We have previously shown with 16α-substituted analogues o
Compounds with hydroxycarbonyl-halogenoalkyl side chain
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, (2008/06/13)
The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the followin
Access to new steroids via a (1,2) Wittig rearrangement
Stephan, Elie,Dousset, Magali,Foy, Nicolas,Jaouen, Gerard
, p. 506 - 507 (2007/10/03)
Novel steroids are obtained by reaction of 9, 11-dehydro- dibenzylestradiol and dibenzylestradiol with phenyllithium in THF at room temperature.
Synthesis of 2-alkoxyestradiols
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, (2008/06/13)
Disclosed is a method of preparing a compound represented by the following structural formula: The method comprises reacting bromine (Br2) and an aliphatic organic acid with a compound represented by the following structural formula: R1 and R2 are each independently a hydroxyl protecting group.
AlCl3-N,N-Dimethylaniline: A Novel Benzyl and Allyl Ether Cleavage Reagent
Akiyama, Takahiko,Hirofuji, Hajimu,Ozaki, Shoichiro
, p. 1932 - 1938 (2007/10/02)
A combination system of AlCl3-N,N-dimethylaniline was found to cleave benzyl ethers readily to give parent alcohols in excellent yields.The system also cleaved allyl as well as methyl ethers.Numerous functional groups such as benzoyloxy, phenylthio, and olefinic double bond were not affected.Comparison of AlCl3-N,N-dimethylaniline and AlCl3-anisole were described.
Potential antineoplastics. 7th Comm.: Introduction of a nitrogen mustard group into the 6α-position of estradiol
Hamacher,Christ
, p. 347 - 352 (2007/10/02)
The nitrogen mustard compound 23 was synthetized as potential antineoplastic drug against estrogen receptor positive tumors from estradiol.
