115920-44-0Relevant articles and documents
Carbazomycin G: Method Development and Total Synthesis
Elumalai, Vijayaragavan,Gambarotti, Cristian,Bj?rsvik, Hans-René
, p. 1984 - 1992 (2018)
A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the initial simple substrate and intermediates. To rea
Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
Bj?rsvik, Hans-René,Gjertsen, Bj?rn Tore,Elumalai, Vijayaragavan
, p. 862 - 870 (2020)
A previously designed and developed 12-step total synthesis that includes [1,1′-biphenyl]-2-amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of
Total synthesis of carbazomycin G by a thermal ring expansion/self-redox reaction cascade
An, Yong,Wang, Yunxia,Hu, Xiangdong
, p. 3715 - 3718 (2014/06/23)
The total synthesis of carbazomycin G (7) has been accomplished in six steps and 26% overall yield starting from commercially available materials. As an efficient access to the tricyclic skeleton of carbazomycins A-H, an interesting thermal ring expansion/self-redox reaction cascade of intermediate 11 has been developed in our study. The self-redox reaction of intermediate 10 can be readily accelerated in the presence of triethylamine, and a plausible reaction mechanism for this process has been proposed. Finally, the synthesis of carbazomycin G was completed by the widely applied regioselective methylation reaction. Copyright
