19299-41-3

Basic information

• Product Name: N-methyl-1-phenylmethanesulfonamide
• CAS NO: 19299-41-3
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.2434
• Mol File: 19299-41-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 314°C at 760 mmHg
• Flash Point: 143.7°C
• Density: 1.217g/cm³
• Vapor Pressure: 0.000478mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: N-methyl-1-phenylmethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-1-phenylmethanesulfonamide(19299-41-3)
• EPA Substance Registry System: N-methyl-1-phenylmethanesulfonamide(19299-41-3)

Safety Data

• Hazardous Substances Data: 19299-41-3(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 1939-99-7 benzenesulfonyl chloride 
• 74-88-4 methyl iodide 
• 675622-48-7 O-benzylsulfonyl-N-[phenyl(1-phenylethyl)phosphinoyl]hydroxylamine 
• 950017-96-6 C₁₆H₁₉NO₃S 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 4563-33-1 phenyl-methanesulfonic acid amide 
• 67-56-1 methanol 
• 57267-76-2 sodium α-toluenesulfonate 
• 57864-65-0 sodium salt of phenylmethanesulfamide 
• 89873-37-0 4-hydroxy-2-methyl-5-phenyl-3(2H)-isothiazolone 1,1-dioxide 

Downstream Products

• 85952-29-0 (4-nitro-phenyl)-methanesulfonic acid methylamide 
• 885373-76-2 N-(cyclohexylmethyl)-1-phenylmethanesulfonamide 
• 89873-37-0 4-hydroxy-2-methyl-5-phenyl-3(2H)-isothiazolone 1,1-dioxide 
• 116043-33-5 N-Methyl-N-((E)-octa-2,7-dienyl)-C-phenyl-methanesulfonamide 
• 803727-96-0 N-methyl-N-(dimethyl-tert-butylsilyl)-1-phenylmethanesulfonamide 
• 106003-76-3 N-methyl-N'-(2,7-octadienyl)-phenylmethanesulfamide 
• 2154-56-5 benzyl radical 

Relevant articles and documents

Acyl vs Sulfonyl Transfer in N-Acyl β-Sultams and 3-Oxo-β-sultams

(Matrix presented) N-Acylsulfonamides usually react with nucleophiles by acyl transfer and C-N bond fission. However, the hydrolysis of N-acyl β-sultams is a sulfonyl transfer reaction that occurs with S-N fission and opening of the four-membered ring. Similar to other β-sultams, the N-acyl derivatives are at least 106-fold more reactive than N-acyl sulfonamides. 3-Oxo-β-sultams are both β-lactams and β-sultams but also hydrolyze with preferential S-N bond fission.

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Method for synthesizing N-methyl sulfonamide in water

The invention discloses a method N - for synthesizing,methylsulfamide in water, by using a transition metal iridium catalyst to catalyze N - methylation reaction. by using a non-toxic and harmless water as a solvent, to avoid using the organic agent; to react only as a byproduct, without an environmental hazard; reaction temperature with respect to the previous strip more mild; and have a wide application prospect; with high selectivity, reaction atomic economy.