19311-38-7Relevant articles and documents
A 3 - halogenated tetrahydrofuran preparation method
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Paragraph 0032; 0033; 0034; 0035; 0036; 0037; 0038-0067, (2019/05/28)
The invention discloses a 3 - halogenated tetrahydrofuran preparation method. The method comprises the following steps: in the organic solvent, 0 - 85 °C temperature, shown in formula I compound with a reducing agent, can be; wherein R1 And R2 The same, they are selected from chlorine or bromine; the reducing agent is sodium borohydride or potassium borohydride; wherein the organic solvent is b [...], 2 - chloroethyl methyl ether, ethyl ether, tetrahydrofuran or methyl tetrahydrofuran. The method of the invention less reaction steps, the process is simple, the product yield can reach 80% - 95%, and the low cost of raw materials, equipment investment, the price of the product there are advantages; in addition the method pollution is small, friendly to the environment, and is suitable for large-scale industrial production.
METHOD FOR PRODUCING 3-AMINOMETHYLTETRAHYDROFURAN DERIVATIVE
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, (2008/06/13)
An object of the present invention is to provide a process for producing a 3-cyanotetrahydrofuran derivative in a high yield from inexpensive industrial materials. According to the present invention, a 3-aminomethyltetrahydrofuran derivative is produced by preparing a 3-cyanotetrahydrofuran derivative in a high yield from an inexpensive and industrially easily available malic acid derivative, and reducing the cyano group of the 3-cyanotetrahydrofuran derivative.
Introduction of bromine and chlorine substituents in medium ring ethers and lactones
Bendall, Justin G.,Payne, Andrew N.,Screen, Thomas E. O.,Holmes, Andrew B.
, p. 1067 - 1068 (2007/10/03)
A convenient preparation of α-halo enamines using oxalyl halides is described together with applications of these reagents in the halogenation of β-hydroxy cyclic ethers and lactones.