1932-67-8

Usage

Structure

Contains a chlorine atom at the 6 position and a methyl group at the 2 position on the quinoxaline ring

Uses

Building block in organic synthesis and pharmaceutical research, potential applications in drug development and bioactive compounds

Properties

Studied for antimicrobial and anti-inflammatory properties, potential applications in medicinal chemistry research

Potential applications

Materials science, due to interesting structural and electronic properties

Upstream product

• 89284-67-3 1-azido-4-methyl-2-nitrobenzene 
• 149179-58-8 1-(4-Chloro-2-nitrophenyl)-4,5-dihydro-4-methyl-5-morpholino-1,2,3-triazole 
• 18671-97-1 2,6-dichloroquinoxaline 
• 75-16-1 methylmagnesium bromide 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 78-98-8 2-oxopropanal 
• 1635-61-6 5-chloro-2-nitroaniline 
• 57-55-6 propylene glycol 
• 89-63-4 4-Chloro-2-nitroaniline 

Relevant academic research and scientific papers

Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts

A Co-based heterogeneous catalyst supported on N,P co-doped porous carbon (Co@NCP) is prepared via a facile in-situ doping-carbonization method. The Co@NCP composite features a large surface area, high pore volume, high-density and strong basic sites. Furthermore, doping of P atoms can regulate the electronic density of Co. Therefore, Co@NCP exhibits good performance for the synthesis of quinoxalines from o-nitroanilines and biomass-derived diols under alkali-free conditions.

ANDROGEN RECEPTOR ANTAGONISTS

Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.

A green synthesis of quinoxalines and 2,3-dihydropyrazines

Quinoxaline and dihydropyrazine derivatives were obtained in high yields by simple addition of 1,2-diamines and 1,2-dicarbonyl compounds in water. In some cases, the products spontaneously precipitated from the reaction mixture, making it possible to recover and reuse the mother liquor for further condensations. The very mild reaction conditions, the high yields of the products, and the absence of any catalyst make this methodology an efficient and green route to quinoxalines and dihydropyrazines. Georg Thieme Verlag Stuttgart New York.

Asymmetric hydrogenation of quinoxalines catalyzed by iridium/PipPhos

A catalyst made in situ from the (cyclooctadiene)iridium chloride dimer, [Ir(COD)Cl]2, and the monodentate phosphoramidite ligand (S)-PipPhos was used in the enantioselective hydrogenation of 2- and 2,6-substituted quinoxalines. In the presence

v-Triazolines. Part 34. Thermal Behavior of 1-(2-Aminophenyl)-4,5-dihydro-5-morpholino-1,2,3-triazoles: New Synthesis of 2-Alkylquinoxalines

4,5-Dihydro-5-morpholino-1-(2-nitrophenyl)-1,2,3-triazoles 4 are prepared by reaction of an aldehyde with morpholine and the appropriate aryl azide.On reduction 1-(2-aminophenyl)-4,5-dihydro-5-morpholino-1,2,3-triazoles 5 are formed.Thermal rearrangement of compounds 5 affords unstable 2-alkyl-3-amino-1,2,3,4-tetrahydroquinoxalines 7, which undergo deamination to 2-alkyl-1,2-dihydroquinoxalines 8.Oxidation of these affords 2-alkylquinoxalines 10.The mechanism of thermal the rearrangement of triazoles 5 is investigated and discussed.