19382-36-6Relevant academic research and scientific papers
Triflic anhydride mediated synthesis of imidazo[1,5-a]azines
Pelletier, Guillaume,Charette, Andre B.
, p. 2290 - 2293 (2013/06/26)
Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active in a Sonogashira cross-coupling and direct arylation reactions. A tertiary amide was compatible as a substrate leading to the synthesis of an imidazo[1,5-a]pyridinium triflate.
REACTIONS OF HETEROCYCLIC N-OXIDES. THE SYNTHESIS OF α-HETEROARYL-α-AMINO ACID DERIVATIVES AND DIPEPTIDES
Jordan, Berta Kotar,Stanovnik, Branko,Tisler, Miha
, p. 657 - 671 (2007/10/02)
Heteroaryl substituted oxazolinylidene derivatives (3) and (4) were converted by opening of the oxazolinone ring under hydrolytic conditions, followed by decarboxylation into acylaminomethyl derivatives (5) and (6), with hydrazine hydrate into the corresp
