194234-97-4

Basic information

• Product Name: 3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one
• Synonyms: (+)-3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one
• CAS NO: 194234-97-4
• Molecular Formula: C16H15NO3
• Molecular Weight: 269.3
• Mol File: 194234-97-4.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 551.3 °C at 760 mmHg
• Flash Point: 287.2 °C
• Appearance: /
• Density: 1.295
• CAS DataBase Reference: 3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one(194234-97-4)
• EPA Substance Registry System: 3-Hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one(194234-97-4)

Safety Data

• Hazardous Substances Data: 194234-97-4(Hazardous Substances Data)

Upstream product

• 40339-42-2 4-methoxy-N-[(1Z)-phenylmethylene]aniline 
• 41625-51-8 trimethylsiloxyacetic acid 
• 186613-02-5 cis-1-p-methoxyphenyl-3-acetoxy-4-phenylazetidin-2-one 
• 104-94-9 4-methoxy-aniline 
• 100-52-7 benzaldehyde 
• 94612-33-6 1-(4-methoxyphenyl)-4-phenylazetidine-2,3-dione 
• 523987-55-5 (3R,4S,2'S,5'S,6'R)-1-(4-methoxyphenyl)-4-phenyl-3-[(2',4',5'-trimethyl-3'-oxo-6'-phenylmorpholin-2'-yl)oxy]azetidin-2-one 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 146924-91-6 (-)-cis-(3S,4R)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 162599-35-1 cis-1-(p-anisyl)-3'S-(4,6-diacetoxy-2,3-enyl-α-O-glycoside)-4R-phenyl-azetidin-2-one 
• 194235-04-6 (3R,4R)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 131968-76-8 (+/-)-(3R,4S)-3-acetoxy-N-(4-methoxyphenyl)-4-phenylazetidin-2-one 
• 153463-27-5 (R)-3-[(3R,4S)-1-(4-Methoxy-phenyl)-2-oxo-4-phenyl-azetidin-3-yl]-4-phenyl-oxazolidin-2-one 
• 101067-78-1 (+/-)-(3R,4S)-3-hydroxy-4-phenyl-N-(4-methoxyphenyl)azetidin-2-one 

Downstream Products

• 1415716-33-4 C₂₁H₂₅NO₄ 
• 162993-22-8 (S)-1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one 
• 37088-64-5 (S)-4-phenyl-2-azetidinone 
• 1067647-06-6 (S)-2-oxo-4-phenyl-azetidine-1-carboxylic acid tert-butyl ester 
• 718611-17-7 S-(3-hydroxy-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 82769-76-4 (S)-3-amino-3-phenylpropanol 
• 144465-78-1 1-(4-Methoxyphenyl)-3-triisopropylsilyloxy-4-phenyl-2-azetidinone 
• 155371-59-8 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 132127-31-2 (3R,4S)-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 146924-91-6 (-)-cis-(3S,4R)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 146924-94-9 (3R,4S)-(+)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 101067-78-1 (+/-)-(3R,4S)-3-hydroxy-4-phenyl-N-(4-methoxyphenyl)azetidin-2-one 
• 94612-33-6 1-(4-methoxyphenyl)-4-phenylazetidine-2,3-dione 
• 156294-36-9 7-deoxy-7β, 8β-methylene-10-O-acetyldocetaxel 

Relevant articles and documents

Ni-Catalyzed asymmetric reduction of α-keto-β-lactams: via DKR enabled by proton shuttling

Chiral α-hydroxy-β-lactams are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective dynamic kinetic resolution (DKR) of α-keto-β-lactams was realized via a novel proton shuttling strategy. A wide range of α-keto-β-lactams were reduced efficiently and enantioselectively by Ni-catalyzed asymmetric hydrogenation, providing the corresponding α-hydroxy-β-lactam derivatives with high yields and enantioselectivities (up to 92% yield, up to 94% ee). Deuterium-labelling experiments indicate that phenylphosphinic acid plays a pivotal role in the DKR of α-keto-β-lactams by promoting the enolization process. The synthetic potential of this protocol was demonstrated by its application in the synthesis of a key intermediate of Taxol and (+)-epi-Cytoxazone. This journal is

Reactivity of 3-Oxo-β-lactams with Respect to Primary Amines—An Experimental and Computational Approach

The reactivity of 3-oxo-β-lactams with respect to primary amines was investigated in depth. Depending on the specific azetidin-2-one C4 substituent, this reaction was shown to selectively produce 3-imino-β-lactams (through dehydration), α-aminoamides (thr

Process for preparation of enantiomerically pure S-(+)-N, N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine

The present invention relates to improved, efficient process for the preparation of enantiomerically pure S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine and pharmaceutically acid addition salts thereof. The present invention particularly provides a process for preparation of (3S, 4R)-3-hydroxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one useful as a key intermediate for preparation of (s)-dapoxetine.