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3-Chloropropanal, also known as 3-chloropropanaldehyde, is a chemical compound with the formula C3H5ClO. It is a colorless to pale yellow liquid with a pungent odor and is slightly soluble in water. 3-chloropropanal is recognized for its role as an intermediate in various chemical syntheses and possesses properties that make it a versatile component in the production of different organic compounds.

19434-65-2

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19434-65-2 Usage

Uses

Used in Pharmaceutical Industry:
3-Chloropropanal is used as an intermediate for the synthesis of various pharmaceuticals. Its reactivity and functional groups allow it to be a key component in the creation of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Pesticide Production:
In the agricultural sector, 3-chloropropanal serves as an intermediate in the production of pesticides. Its chemical properties make it suitable for the synthesis of active ingredients that help protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Organic Chemistry as a Reagent:
3-Chloropropanal is utilized as a reagent in organic chemistry reactions. Its ability to participate in a variety of chemical processes, such as oxidation, reduction, and condensation reactions, makes it a valuable tool for researchers and chemists in the synthesis of complex organic molecules.
Safety Note:
It is important to acknowledge that 3-chloropropanal is known to be an irritant to the skin, eyes, and respiratory system. Therefore, it should be handled with caution, and safety precautions must be strictly followed to minimize the risk of exposure and prevent adverse health effects.

Check Digit Verification of cas no

The CAS Registry Mumber 19434-65-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,3 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19434-65:
(7*1)+(6*9)+(5*4)+(4*3)+(3*4)+(2*6)+(1*5)=122
122 % 10 = 2
So 19434-65-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H5ClO/c4-2-1-3-5/h3H,1-2H2

19434-65-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-chloropropanal

1.2 Other means of identification

Product number -
Other names Propanal, 3-chloro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19434-65-2 SDS

19434-65-2Related news

IR-induced photorotamerization of propanal and 3-chloropropanal (cas 19434-65-2) in low-temperature matrices. Ab initio optimization of conformer geometries, and calculation of torsional barrier heights08/17/2019

Propanal and 3-chloropropanal have been studied in solid Ar and N2 matrices. A fast IR-induced cis → gauche process was found for propanal, whereas the reverse process occurred in the dark upon warming the matrices. A very fast process was found for 3-chloropropanal in Ar; in N2 it was 60 times...detailed

19434-65-2Relevant academic research and scientific papers

New series of double-modified colchicine derivatives: Synthesis, cytotoxic effect and molecular docking

Aminpour, Maral,Huczyn?ski, Adam,Krzywik, Julia,Maj, Ewa,Mozga, Witold,Tuszyn?ski, Jack A.,Wietrzyk, Joanna

, (2020)

Colchicine is a well-known anticancer compound showing antimitotic effect on cells. Its high cytotoxic activity against different cancer cell lines has been demonstrated many times. In this paper we report the syntheses and spectroscopic analyses of novel colchicine derivatives obtained by structural modifications at C7 (carbon-nitrogen single bond) and C10 (methylamino group) positions. All the obtained compounds have been tested in vitro to determine their cytotoxicity toward A549, MCF-7, LoVo, LoVo/DX, and BALB/3T3 cell lines. The majority of obtained derivatives exhibited higher cytotoxicity than colchicine, doxorubicin and cisplatin against the tested cancerous cell lines. Additionally, most of the presented derivatives were able to overcome the resistance of LoVo/DX cells. Additionally, their mode of binding to β-tubulin was evaluated in silico. Molecular docking studies showed that apart from the initial amides 1 and 2, compound 14, which had the best antiproliferative activity (IC50 = 0.1–1.6 nM), stood out also in terms of its predicted binding energy and probably binds best into the active site of βI-tubulin isotype.

ANTIMICROBIAL COMPOSITIONS, METHODS OF MAKING, AND METHODS OF USE

-

Paragraph 0011; 0013, (2019/03/08)

The invention provides a protected antimicrobial compound and methods of using the same.

Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers

Miller, Kali A.,Morado, Ephraim G.,Samanta, Shampa R.,Walker, Brittany A.,Nelson, Arif Z.,Sen, Samya,Tran, Dung T.,Whitaker, Daniel J.,Ewoldt, Randy H.,Braun, Paul V.,Zimmerman, Steven C.

supporting information, p. 2838 - 2842 (2019/03/05)

We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (pKa-10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.

PROTECTED CARBOXYLIC ACID-BASED METABOLITES FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS

-

Page/Page column 50, (2017/07/29)

The present invention provides novel cell-permeable carboxylic acid-based metabolites and cell permeable precursors thereof aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr

METHOD FOR THE CATALYTIC REDUCTION OF ACID CHLORIDES AND IMIDOYL CHLORIDES

-

Paragraph 0104, (2014/08/19)

The present application relates to methods for the catalytic reduction of acid chlorides and/or imidoyl chlorides. The methods comprise reacting the acid chloride or imidoyl chloride with a silane reducing agent in the presence of a catalyst such as [Cp(Pri3P)Ru(NCMe)2]+[PF6]?.

Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles

MacK, Daniel J.,Batory, Lindsay A.,Njardarson, Jon T.

supporting information; experimental part, p. 378 - 381 (2012/03/09)

Detailed in this account are our efforts toward efficient oxacycle syntheses. Two complementary approaches are discussed, with both employing chemoselective allyl ether activation and rearrangement as the key step. Vinyl substituted oxiranes and oxetanes provide a single step access to dihydropyrans and tetrahydrooxepines. Oxiranes proved to be poor substrates, while oxetanes were slightly better. An alternative approach using substituted allyl ethers proved successful and addressed the limitations encountered in the ring expansions.

Chemoselective ruthenium-catalyzed reduction of acid chlorides to aldehydes with dimethylphenylsilane

Gutsulyak, Dmitry V.,Nikonov, Georgii I.

experimental part, p. 607 - 611 (2012/04/23)

A variety of aromatic and alkyl acid chlorides can be selectively converted into aldehydes using dimethylphenyl silane (HSiMe2Ph) as the reducing reagent in the presence of the cationic ruthenium catalyst {Cp[(i-Pr)3P]Ru(NCMe)2}+ [PF6] -. The reactions proceed under very mild conditions and are tolerant to many functional groups. Copyright

Amido macrolides

-

, (2008/06/13)

Various macrolide compounds such as those having the following formulas are provided where the variables have the values provided herein.

Amido macrolides

-

Page/Page column 25, (2010/01/31)

Various macrolide compounds such as those having the following formulas are provided where the variables have the values provided herein.

N-(4-methylbenzenesulfonyl)- pyrrolidines and piperidines by a tandem S(N)2-Michael addition reaction

Bunce, Richard A.,Allison, Jeffrey C.

, p. 2175 - 2186 (2007/10/03)

A tandem S(N)2-Michael addition sequence has been developed for the preparation of N-(4-methylbenzenesulfonyl)- pyrrolidines and piperidines bearing functionalized side chains at C-2.

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