19449-26-4

Basic information

• Product Name: 2-Dimethylamino-1,3-dioxolane
• Synonyms: 2-DIMETHYLAMINO-1,3-DIOXOLANE;N,N-DIMETHYLFORMAMIDE ETHYLENE ACETAL;N,N-dimethyl-1,3-dioxolan-2-amine;2-Dimethylamino-1,3-dioxocyclopentane;1,3-Dioxolan-2-aMine,N,N-diMethyl-
• CAS NO: 19449-26-4
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• EINECS: 243-075-7
• Mol File: 19449-26-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 142-144 °C(lit.)
• Flash Point: 38°C
• Appearance: /
• Density: 1.015 g/mL at 20 °C(lit.)
• Vapor Pressure: 5.85mmHg at 25°C
• Refractive Index: n20/D 1.429
• PKA: 5.00±0.20(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 773813
• CAS DataBase Reference: 2-Dimethylamino-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Dimethylamino-1,3-dioxolane(19449-26-4)
• EPA Substance Registry System: 2-Dimethylamino-1,3-dioxolane(19449-26-4)

Safety Data

• Statements: 10
• Safety Statements: 23-24/25
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 3-10-21
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 19449-26-4(Hazardous Substances Data)

Usage

General Description

2-Dimethylamino-1,3-dioxolane is a chemical compound with the formula C6H13NO2. It is a colorless liquid with a slightly amine-like odor, and it is commonly used as a reagent in organic synthesis. 2-Dimethylamino-1,3-dioxolane is also known for its ability to serve as a protecting group for alcohols in organic chemistry, allowing for selective reactions to occur without interference from the alcohol functional group. Additionally, it can be used as a solvent or as a precursor for the synthesis of pharmaceuticals and other organic compounds. Its properties and applications make it a valuable and versatile chemical in the field of organic synthesis and industrial chemistry.

InChI:InChI=1/C5H11NO2/c1-6(2)5-7-3-4-8-5/h5H,3-4H2,1-2H3

Upstream product

• 107-21-1 ethylene glycol 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 1073-75-2 2-(2'-hydroxyethoxy)-1,3,2-dioxaphospholane 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 3646-10-4 1,4,6,9-tetraoxa-5λ₅-phosphaspiro[4,4]nonane 

Downstream Products

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 183-97-1 1,4,9,12-Tetraoxa-dispiro[4.2.4.2]tetradecane 
• 687-48-9 ethyl N,N-dimethylcarbamate 
• 107-21-1 ethylene glycol 
• 68-12-2 N,N-dimethyl-formamide 
• 96-49-1 [1,3]-dioxolan-2-one 
• 140-08-9 tris(2-chloro-ethyl)phosphite 

Relevant articles and documents

N-Alkylation of 4-Chloro-5-cyano-1,2,3-triazole with Orthoformic Acid Derivatives

The N-alkylation of 4-chloro-5-cyano-1,2,3-triazole with methyl and ethyl orthoformate, and the dimethyl, diethyl and ethylene acetals of DMF has been examined.Methylation gives all three N-methyl isomers, whereas ethylation and hydroxyethylation gives 2-N-alkyl derivatives only.It has been shown for the first time that it is possible to use DMF ethylene acetal to obtain N-hydroxyethylazoles.The structure of the products were established by 13C NMR spectroscopy.

NEW TYPES OF AMINOMETHYL ORGANOPHOSPHORUS COMPOUNDS

We studied aminomethylation of various PH acids their derivatives containing highly reactive PH, PSi, POSi and PC(O) fragments: tris(trimethylsilyl)phosphine, trimethylsilyl esters of phosphorus(III) acids, pivaloylphosphonite, and hydrospirophosphoranes.Chloro-, alkoxy- or dialkylaminomethylamines, dialkylformamide acetals, azomethines, and enamines were used as aminomethylating reagents.Convenient methods for synthesizing previously unknown or difficult-to-obtain organic compounds of two-, three-, four, and five-coordinate phosphorus containing a P-C-N fragment were proposed.