N-Alkylation of 4-Chloro-5-cyano-1,2,3-triazole with Orthoformic Acid Derivatives

Article abstract of DOI:10.1007/BF00633170

The N-alkylation of 4-chloro-5-cyano-1,2,3-triazole with methyl and ethyl orthoformate, and the dimethyl, diethyl and ethylene acetals of DMF has been examined.Methylation gives all three N-methyl isomers, whereas ethylation and hydroxyethylation gives 2-N-alkyl derivatives only.It has been shown for the first time that it is possible to use DMF ethylene acetal to obtain N-hydroxyethylazoles.The structure of the products were established by 13C NMR spectroscopy.