19485-86-0Relevant academic research and scientific papers
Spasmolytic Agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine Derivatives
Kanao, Munefumi,Hashizume, Takeshi,Ichikawa, Yoshifumi,Irie, Kiyoshi,Isoda, Sumiro
, p. 1358 - 1363 (2007/10/02)
N--1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines evaluated for their spasmolytic activity.Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine).The biological data have indicated some structure-activity relationships.Among these compounds, N-ethyl-N-hexyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride (63) was found to be the most active spasmolytic agent.
Comparison of Biological Effects of N-Alkylated Congeners of β-Phenylethylamine Derived from 2-Aminotetralin, 2-Aminoindan, and 6-Aminobenzocycloheptene
Cannon, Joseph G.,Perez, Julio A.,Pease, Jonathan P,Long, John Paul,Flynn, Jan R.,et al.
, p. 745 - 749 (2007/10/02)
Three series of bicyclic, semirigid congeners of β-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions.Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivatives, but was not found with 6-aminobenzocycloheptene derivatives.Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects.This action was not blocked by pretreatment with naloxone.
