19507-22-3

Upstream product

• 57162-72-8 4-phenyl<5H>indeno<1,2-b>pyridine 
• 5706-12-7 (E)-2-benzylidene-2,3-dihydro-1H-inden-1-one 
• 107-91-5 cyanoacetic acid amide 
• 71-43-2 benzene 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 5381-33-9 2-benzylidene-indan-1,3-dione 

Downstream Products

• 101148-22-5 2,4-diphenyl-5H-indeno[1,2-b]pyridin-5-ol 

Relevant academic research and scientific papers

4-Azafluorenone and α-Carboline fluorophores with green and violet/blue emission

The emission properties of three 4-azafluorenone and five new α-carboline fluorophores in both solution and thin solid films were investigated. Fluorescence of the azafluorenone is clearly enhanced in thin solid films due to the presence of phenyl/biphenyl rotors, and these derivatives can be classified as green Aggregation-Induced Emission luminogens (AIEgens) with a non-emissive heteroaromatic core structure. Compared to azafluorenones, emission of α-carbolines is hypsochromically shifted to the blue region of the electromagnetic spectrum, and most of these derivatives exhibit strong violet-blue fluorescence in both solution and thin solid film layers. Further, the effective mobility and electroluminescence of new α-carbolines were investigated in prepared organic field-effect transistors and organic light-emitting diodes, respectively.

A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships

DNA Topoisomerase IIα (topo IIα) is one of the most effective therapeutic targets to control cancer. In an effort to develop novel and effective topo IIα targeting anti-proliferative agent, a phenolic series of indenopyridinone and indenopyridinol were designed and prepared using efficient multi-component one pot synthetic method. Total twenty-two synthesized compounds were assessed for topo I and IIα inhibition, and anti-proliferation in three different human cancer cell lines. Overall structure-activity relationship study explored the significance of meta-phenolic group at 4-position and para-phenolic group at 2- and/or 4-position of indenopyridinone skeleton for strong topo IIα-selective inhibition and anti-proliferative activity against human cervix (HeLa) and colorectal (HCT15) cell lines. Compound 12 with excellent topo IIα inhibition (93.7%) was confirmed as a DNA intercalator that could be a new promising lead to develop effective topo IIα-targeted anticancer agents.

On the Reaction of N-Vinyliminophosphoranes. Part 16. A New Synthesis of 5H-Indenopyridines and 5H-Indenopyridin-5-ones

Thermal reaction of tributyl(inden-3-ylimino)phosphorane with α,β-unsaturated ketones and aldehydes led to a Michael-type C-C bond formation and subsequent aza-Wittig reaction to give 5H-indeno(1,2-b)pyridines in good to modest yield.The products were oxidized conveniently by chromium trioxide and t-butyl hydroperoxide to give 5H-indenopyridin-5-ones, including the 4-azafluorenone alkaloid onychine.