1951-12-8

Usage

Uses

Used in Organic Synthesis:
3-Chlorobutyric acid is used as a building block in the synthesis of various organic compounds. Its reactivity and functional groups make it a valuable intermediate in the preparation of a wide range of chemical products.
Used in Pharmaceutical Production:
3-Chlorobutyric acid is used as an intermediate in the production of pharmaceuticals. Its chemical properties allow it to be incorporated into the structures of various drugs, contributing to their therapeutic effects.
Used in Agrochemical Production:
3-Chlorobutyric acid is used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical structure plays a role in the development of these products, which are designed to protect crops and control pests.
Used in the Production of γ-Butyrolactone:
3-Chlorobutyric acid is used as a precursor in the production of γ-butyrolactone, which is a versatile compound with applications in various industries. It serves as a solvent, an intermediate in the production of polymers, and a precursor to other chemicals, making it an important component in the chemical manufacturing process.

InChI:InChI=1/C4H7ClO2/c1-3(5)2-4(6)7/h3H,2H2,1H3,(H,6,7)/t3-/m0/s1

Upstream product

• 81608-88-0 3-chlorobutyraldehyde 
• 109-75-1 but-3-enenitrile 
• 3724-65-0 2-butenoic acid 
• 7732-18-5 water 
• 107-92-6 butyric acid 
• 107-93-7 (E)-but-2-enoic acid 
• 67-63-0 isopropyl alcohol 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 7782-50-5 chlorine 
• 7647-01-0 hydrogenchloride 
• 2835-82-7 3-aminobutyric acid 
• 2203-35-2 3-chloro-1-butanol 

Downstream Products

• 62108-76-3 3-chloro-butyric acid isobutyl ester 
• 6072-57-7 3-methylindanone 
• 26473-49-4 3-mercaptobutyric acid 
• 107-93-7 (E)-but-2-enoic acid 
• 880-13-7 2-hydroxycarbonyl-1-methylethyl phenyl sulfide 
• 24552-31-6 β-(4-hydroxy-3-methylphenyl)butyric acid 
• 6739-21-5 3-(4-hydroxy-phenyl)-butyric acid 
• 625-35-4 trans-chrotonyl chloride 
• 1951-11-7 3-chlorobutanoyl chloride 
• 107-92-6 butyric acid 
• 187737-37-7 propene 
• 625-38-7 but-3-enoic acid 
• 4593-90-2 3-phenylbutyric acid 
• 18076-12-5 Crotonsaeure-<2-amino-anilid> 

Relevant academic research and scientific papers

HYDROCHLORINATION OF ELECTRON-DEFICIENT ALKENES

The present invention pertains to a method for the hydrochlorination of electron deficient alkenes, particularly alkenes having the functional groups COOH, CONH2, and CN. Specific alkenes discussed include acrylic acid, crotonic acid, methacrylic acid, acrylonitrile, acrylamide, and methacrylonitrile. The alkene is combined with a primary or secondary alcohol (e.g., isopropanol) and an acid chloride (e.g., acetyl chloride) under conditions suitable to chlorinate the alkene. Products formed by the invention include 3-chorosubstituted carbonyl compounds such as 3-chlorpropionic acid (3-CPA), 3-chloropropionamide (3-CPAD), and 3-chloropropionitrile among other products.

Activation of the silicon-halogen bond by bismuth (III) halides. Halogenation of alcohols: prospective and mechanism

In the presence of catalytic amount of BiCl3, chloromethylsylanes can be used as chlorinating agents for alcohols, and as chloro-dealkylating agents for silyl ethers and carboxylic and sulfonic esters.The chlorination of (R)-(-)-octan-2-ol and the (R)-(-)-2-mesyloctane by TMSCl gave predominantly the (S)-(+)-2-chlorooctane with inversion of configuration at secondary carbon.According to the class of alcohol, the mechanism involves SN2, SN2' or SN1 processes.This new activation of the Si-Cl bond, probably trough a Si-Cl...BiCl3 interaction gives a hard-soft reagent that can generate a silicenium cation, was also observed with Me3SiBr, BiBr3 and Me3SiI, BiI3 systems.The reaction is also presented as a possible alcoholysis of chlorosilanes, which can lead to siloxanes in non-aqueous conditions. catalysis / halogenation / alcohol / ester / silyl ether / chlorosilane / chlorotrimethylsilane / bromotrimethylsilane / iodotrimethylsilane / siloxane / bismuth (III) halide

AN IMPROVED SYNTHESIS OF HEXAMETHYLPHENALENE

The synthesis of 1,3,4,6,7,9-hexamethylphenalene (2) has been improved from 15 steps to a four step procedure.The overall yield has been increased from an estimated 5percent to 45percent.Key steps in the synthesis are the reaction of 3,5-dimethylbenzylmagnesium chloride with 2,4-pentanedioato lithium in THF to make 5-(3,5-dimethylphenyl)-4-methyl-4-hydroxy-2-pentanone (5) and the Lewis acid acylation-alkation of 1,3,6,8-tetramethylnaphthalene using 3-chlorobutanoic chloride in hexane with sonicaton to make 1,3,4,6,7,9-hexamethyl-phenalane (2).

HYDROCHLORINATION OF VINYL AND ALLYL ACRYLATES AND TRANS-CROTONATES

Different orders of addition were established for the addition of hydrogen chloride to vinyl and allyl acrylates and trans-crotonates.The hydrochlorination of vinyl and allyl acrylates takes place regioselectively at the double bond of the acrylic system.The hydrochlorination of vinyl and allyl trans-crotonates takes place at the double bond of the alkenoxy group.Vinyl β-chloropropionate and β-chlorobutyrate were also obtained by transvinylation of the acids with vinyl acetate.The ability of the obtained chloroesters to undergo certain chemical transformations was demonstrated.