54795-05-0Relevant academic research and scientific papers
Nickel-Catalyzed Ring Expansion of Cyclobutanones towards Indanones
Chen, Tengyun,Wu, Yunkai,Han, Peilin,Gao, Jiqiang,Wu, Yuanqi,Zhao, Jinbo,Liang, Haotian,Liu, Yongsheng,Liu, Yu
, (2022/01/13)
Despite recent advances in catalytic ring-opening/cross-coupling process of o-halogen tethered phenylcyclobutanones with other partners, single-component ring expansion of such precursors towards 3-methylindanones has not been disclosed. We present herein a nickel catalyzed C?C bond reconstruction sequence of o-bromophenylcyclobutanones using H2O as hydrogen donor, leading to a series of indanones, which can be further converted into other benzene-fused cyclic compounds.
Two-carbon ring expansion of 1-indanones via insertion of ethylene into carbon-carbon bonds
Xia, Ying,Ochi, Shusuke,Dong, Guangbin
, p. 13038 - 13042 (2019/08/26)
A rhodium-catalyzed direct insertion of ethylene into a relatively unstrained carbon-carbon bond in 1-indanones is reported, which provides a two-carbon ring expansion strategy for preparing seven-membered cyclic ketones. As many 1-indanones are commercially available and ethylene is inexpensive, this strategy simplifies synthesis of benzocycloheptenones that are valuable synthetic intermediates for bioactive compounds but challenging to prepare otherwise. In addition, the reaction is byproduct-free, redox neutral, and tolerant of a wide range of functional groups, which may have implications on unconventional strategic bond disconnections for preparing complex cyclic molecules.
