19549-84-9

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

InChI:InChI=1/C9H18O/c1-5-7(3)9(10)8(4)6-2/h7-8H,5-6H2,1-4H3/t7-,8-/m0/s1

Upstream product

• 78-09-1 orthocarbonic acid tetraethyl ester 
• 671795-46-3 sec-butylmagnesium bromide 
• 75-03-6 ethyl iodide 
• 96-22-0 pentan-3-one 
• 123-19-3 4-heptanone 
• 74-88-4 methyl iodide 
• 5325-94-0 N-Ethoxycarbonylpiperidine 
• 598-30-1 sec.-butyllithium 
• 116-53-0 2-Methylbutanoic acid 
• 67-56-1 methanol 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 4784-77-4 (E/Z)-crotyl bromide 
• 34575-26-3 2-(sec-butyl)-4,4-dimethyl-2-oxazoline 
• 78-86-4 s-butyl chloride 

Downstream Products

• 19549-79-2 3,5-dimethylheptan-4-ol 

Relevant academic research and scientific papers

Application of catalytic dynamic resolution of N-Boc-2-lithiopiperidine to the asymmetric synthesis of 2-aryl and 2-vinyl piperidines

The highly enantioselective synthesis of 2-aryl-and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.

Catalytic synthesis of oxygenate from alcohol

The present invention discloses a method for catalytic synthesis of oxygenate from alcohol. At first, a feeding material comprising at least one alcohol is provided. Next, a copper-containing catalyst is provided and the catalyst further comprises at least one metal element selected from the group consisting of the following: zinc, magnesium, and aluminum elements. Following that, a catalytic reaction of the feeding material over the copper-containing catalyst is carried out to synthesize at least one oxygenate.

N-CARBOETHOXYPIPERIDINE, A CONVENIENT REAGENT FOR THE PREPARATION OF SYMMETRICAL KETONES FROM ORGANOLITHIUMS

N-Carboethoxypiperidine on reaction with organolithium reagents, RLi, followed by acidic work-up gave excellent yields of the corresponding symmetrical ketones, R2CO.

CHOLESTEROL-LOWERING AGENTS

This invention relates to compounds of structural formula (I): which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of famesyl protein transferase and famesylation of the oncogene protein Ras and thus useful in treating cancer.

α-Methylation of ketones via manganese-enolates: Absence of undesired polyalkylation

The transmetalation of ketone lithium-enolates using MnBr2 generates manganese-enolates which react with CH3I to provide α-methylated ketones with essentially no undesired polyalkylated byproducts.

Methylation of cyclohexanone with simultaneous dehydrogenation

Catalytic process for alkylating ketones carrying at least one methyl or methylene group in α-position to the carbonyl group by reacting them with primary alcohols in the presence of copper and/or silver catalysts.