19718-88-8

Basic information

• Product Name: 1,4-Diazaspiro[4.5]decan-2-one
• Synonyms: 1,4-Diazaspiro[4.5]decan-2-one
• CAS NO: 19718-88-8
• Molecular Formula: C₈H₁₄N₂O
• Molecular Weight: 154
• Mol File: 19718-88-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Diazaspiro[4.5]decan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Diazaspiro[4.5]decan-2-one(19718-88-8)
• EPA Substance Registry System: 1,4-Diazaspiro[4.5]decan-2-one(19718-88-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19718-88-8(Hazardous Substances Data)

Usage

General Description

1,4-Diazaspiro[4.5]decan-2-one, also known as decahydropyrrolo[3,4-b]pyrrole-2-one, is a heterocyclic compound with a spiro backbone. It is a bicyclic compound containing two nitrogen atoms and a lactam ring. This chemical has applications in the pharmaceutical industry, where it is used as a building block in the synthesis of various biologically active molecules. It has been studied for its potential as a drug candidate for the treatment of neurological disorders and other conditions. Additionally, it is used in organic synthesis and has been investigated for its antimicrobial and antifungal properties.

Upstream product

• 124-41-4 sodium methylate 
• 108-94-1 cyclohexanone 
• 540-61-4 2-aminoacetonitrile 
• 598-41-4 H-Gly-NH₂ 
• 1668-10-6 glycinamide hydrochloride 

Downstream Products

• 936240-33-4 1-benzyl-4-oxy-1,4-diaza-spiro[4.5]dec-3-en-2-one 
• 936240-34-5 2-benzyloxy-1,4-diaza-spiro[4.5]deca-1,3-diene 4-oxide 
• 936240-32-3 4-oxy-1,4-diaza-spiro[4.5]dec-3-en-2-one 

Relevant articles and documents

"Dry" and "wet" green synthesis of 2,2′ -disubstituted quinazolinones

An extremely convenient, environmentally benign spirocyclization under either aqueous or solventless conditions, developed for the preparation of spiro[cyclohexane-l,2′(l′H)-quinazolin]-4′(3′H)-one (3), has been utilized to convert α- and β-aminocarboxamides 5a, 5b, 6a-c and 9 and cycloalkanones 2-2b and alkanones 2c-e into 1,4-diazaspiro[4.5]decan- 2-one (10) and cis-, diexo- or diendo-2,2′-disub-stituted quinazolinones 5a, 5b, 7a-f and 8. diexo-Methylenebridged carboxamides 6a and 6b were treated "on water" with N-benzylpiperidinone (11) to afford spiropiperidinequinazolinones 12a and 12b. All these reactions were performed at room temperature, without any catalyst or co-solvent, and gave yields of up to 99%.

Versatile spirocyclic glycine-based nitrones and their highly stereoselective 1,3-dipolar cycloaddition

A convenient and efficient method for the synthesis of novel spirocyclic nitrones prepared from glycine derivatives is reported. The 1,3-cycloaddition reactions of the nitrones with alkenes lead to novel isoxazolidines in high yields and with excellent re