197902-91-3Relevant articles and documents
A synthetic route for the generation of C-7 substituted azepinones
Robl, Jeffrey A.,Cimarusti, Maria P.
, p. 1393 - 1396 (1994)
A versatile method for the synthesis of 3-amino azepinones possessing alkyl substitution at the C-7 position is described. Compounds of this type may be viewed as conformationally restricted dipeptide surrogates.
Vasopeptidase inhibitors: Incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides
Robl, Jeffrey A.,Sulsky, Richard,Sieber-McMaster, Ellen,Ryono, Denis E.,Cimarusti, Maria P.,Simpkins, Ligaya M.,Karanewsky, Donald S.,Chao, Sam,Asaad, Magdi M.,Seymour, Andrea A.,Fox, Maxine,Smith, Patricia L.,Trippodo, Nick C.
, p. 305 - 311 (2007/10/03)
A series of 7-(di)alkyl and spirocyclic substituted azepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. Clear structure-activity relationships with respect to both angiotensin-converti
