84688-13-1Relevant academic research and scientific papers
N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors
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Page column 20, (2010/02/08)
N-formyl hydroxylamines are provided which have the structure wherein R is H, alkyl, alkenyl, aryl-(CH2)p—, heteroaryl-(CH2)p— or cycloheteroalkyl-(CH2)p— R1is H or COR2where R2is alkyl, aryl-(CH2)p—, cycloheteroalkyl-(CH2)p—, heteroaryl-(CH2)p—, alkoxy or cycloalkyl-(CH2)p—, p is 0 to 8, and A is a dipeptide derived from an amino acid or is a conformationally restricted dipeptide mimic. The above compounds are useful in treating hypertension congestive heart failure, renal failure, and hepatic cirrhosis.
Vasopeptidase inhibitors: Incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides
Robl, Jeffrey A.,Sulsky, Richard,Sieber-McMaster, Ellen,Ryono, Denis E.,Cimarusti, Maria P.,Simpkins, Ligaya M.,Karanewsky, Donald S.,Chao, Sam,Asaad, Magdi M.,Seymour, Andrea A.,Fox, Maxine,Smith, Patricia L.,Trippodo, Nick C.
, p. 305 - 311 (2007/10/03)
A series of 7-(di)alkyl and spirocyclic substituted azepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. Clear structure-activity relationships with respect to both angiotensin-converti
A synthetic route for the generation of C-7 substituted azepinones
Robl, Jeffrey A.,Cimarusti, Maria P.
, p. 1393 - 1396 (2007/10/02)
A versatile method for the synthesis of 3-amino azepinones possessing alkyl substitution at the C-7 position is described. Compounds of this type may be viewed as conformationally restricted dipeptide surrogates.
BICYCLIC LACTAMS
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, (2008/06/13)
The invention relates to bicyclic lactams and related compounds which are useful as antihypertensives.
