19836-23-8Relevant articles and documents
Catalytic C?H/C?F Coupling of Azoles and Acyl Fluorides
Ogiwara, Yohei,Iino, Yurika,Sakai, Norio
supporting information, p. 6513 - 6516 (2019/04/27)
A method for the palladium/copper-catalyzed direct acylation of azoles with acyl fluorides is described. This study reports the first examples of acyl fluorides being used as acylation reagents in transition-metal-catalyzed aromatic C?H bond functionalization reactions. Depending on the reaction temperature, decarbonylative coupling may also occur. Mechanistic studies suggest that the cleavage of the aromatic C?H bond, promoted by a copper-phosphine species, is not the rate-limiting step of this acylation.
Pd-Catalyzed Csp2-H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines
Sharma, Upendra K.,Sharma, Nandini,Xu, Jun,Song, Gonghua,Van Der Eycken, Erik V.
, p. 4908 - 4912 (2015/03/30)
We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.
A facile and expeditious one-pot synthesis of α-Keto-1,3,4- oxadiazoles
Kumar, Dalip,Pilania, Meenakshi,Arun,Mishra, Bhupendra
, p. 1137 - 1141 (2014/05/20)
An efficient and high-yielding protocol for the preparation of α-keto-1,3,4-oxadiazoles has been developed. Formation of α-keto-1,3,4-oxadiazoles involves the 2-iodoxybenzoic acid/ tetraethylammonium bromide mediated oxidative cyclization of hydrazide-hyd
