5131-58-8 Usage
Chemical Properties
Yellow crystal powder
Uses
4-Nitro-1,3-diaminobenzene is a general chemical reagent used in the synthesis of pharmaceuticals. Used in the synthesis of potent and selective Chk-1 inhibitors in the treatment of various cancers.
General Description
Orange prisms with blue luster or yellow crystalline solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Nitro-1,3-phenylenediamine is an amine/organonitrate. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Flash point data for 4-Nitro-1,3-phenylenediamine are not available, but 4-Nitro-1,3-phenylenediamine is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 5131-58-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,3 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5131-58:
(6*5)+(5*1)+(4*3)+(3*1)+(2*5)+(1*8)=68
68 % 10 = 8
So 5131-58-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H7N3O2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H,7-8H2
5131-58-8Relevant articles and documents
Method of producing 4-nitro-m-phenylenediamine sulfate
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, (2008/06/13)
A method of manufacture of 4-nitro-m-phenylenediamine sulfate is taught. The resultant compound is useful in the dyeing of keratinic fibers, particularly, human hair. It exhibits reduced toxicity and potential for damage to such fibers, and is easier to remove than are other known compounds.
Possible Anthelmintic Agents: Syntheses of Various Imidazoquinazolinone Carbamates
Kumar, Shiv,Kansal, V. K.,Bhaduri, A. P.
, p. 1068 - 1071 (2007/10/02)
Two of the three possible imidazoquinazolinone-2-carbamates representing angular and linear heterocyclic systems, have been synthesised and evaluated for their anthelmintic activity.During the course of the synthesis of ethyl or methyl 7-alkylimidazoquinazolin-8-one-2-carbamate, it is observed that the reaction of 3-alkyl-7-chloro-6-nitroquinazolin-4-ones with butanol saturated with aq.NH3, furnishes a number of ring-opened products which have been characterised on the basis of elemental analyses, IR, PMR and mass spectral data.The same reaction when carried out with dry NH3, furnishes the desired amino-nitro derivatives.UV and IR spectra of the linear and angular imidazoquinazolinones have also been compared.
