19865-87-3

Basic information

• Product Name: Cabralealactone
• Synonyms: Cabralealactone;Tris(norketo)lactone II
• CAS NO: 19865-87-3
• Molecular Formula: C₂₇H₄₂O₃
• Molecular Weight: 414.62
• Mol File: 19865-87-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 183 °C
• Boiling Point: 516.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.057±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Cabralealactone(CAS DataBase Reference)
• NIST Chemistry Reference: Cabralealactone(19865-87-3)
• EPA Substance Registry System: Cabralealactone(19865-87-3)

Safety Data

• Hazardous Substances Data: 19865-87-3(Hazardous Substances Data)

Usage

General Description

Cabralealactone is a naturally occurring compound isolated from the fungus Penicillium, and it belongs to the class of sesquiterpenoids. It has been reported to exhibit a variety of biological activities, including anti-inflammatory, antifungal, and cytotoxic effects. Research has shown that cabralealactone inhibits the production of nitric oxide and prostaglandin E2, which are involved in the inflammatory response. Additionally, it has demonstrated antifungal activity against various strains of fungi, making it a potential candidate for the development of new antifungal drugs. Furthermore, cabralealactone has also shown cytotoxic effects against cancer cells in vitro. Overall, cabralealactone appears to be a promising natural compound with potential therapeutic applications.

Upstream product

• 67253-01-4 20S,24S-epoxydammarane-3α,25-diol 
• 35761-54-7 25-hydroxy-(20S,24S)-epoxydammaran-3-one 
• 1414789-27-7 (20S,24RS)-23,24-epoxy-24-hydroxy-25,26,27-trinordammaran-3-one 
• 67-56-1 methanol 
• 471-69-2 dipterocarpol 
• 67-63-0 isopropyl alcohol 
• 35833-62-6 20S,24S-epoxydammarane-25-ol-3α-yl acetate 
• 53822-98-3 3ξ,20(S),24ξ-trihydroxydammar-25-ene 

Downstream Products

• 927799-54-0 25,26,27-trinordammaran-3β-ol-20(S),24-olide hydrogen phthalate 
• 927799-53-9 25,26,27-trinor-20(S),24-epoxydammaran-3β-ol hydrogen phthalate 

Relevant articles and documents

Synthesis of 2-Mono- and 2,2-Bis[2-(1H-tetrazol-5-yl)ethyl] Derivatives of Dipterocarpol

The azidation of 2,2-bis(2-cyanoethyl)-20-hydroxydammar-24-en-3-one afforded new tetrazole derivatives of natural dipterocarpol, 2-(2-cyanoethyl)-2-[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en- 3-ones, 2,2-bis[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en-3-one, and 2,2-bis[2-(1H-tetrazol-5-yl)- ethyl]-3-oxo-25,26,27-trinordammaran-(20S),24-olide. The structure of the final and intermediate products was determined by NMR spectroscopy and X-ray analysis.

VELLOZONE, A TETRACYCLIC TRITERPENE FROM VELLOZIA STIPITATA

The isolation of (20R)-20-hydroxy-24-methylenedammar-3-one from Vellozia stipitata is described. - Key Word Index: Vellozia stipitata; V. aloifolia; Velloziaceae; tetracyclic triterpene; (20R)-20-hydroxy-24-methylenedammar-3-one.

Ozonolysis of dipterocarpol and its derivatives

Oxidation of dipterocarpol and its derivatives with ozone gave compounds containing lactone, lactol, alkoxytetrahydrofuran, aldehyde, and methyl ketone fragments in the side chain, as well as 1,2,4-trioxolane fragment in the A ring. The molecular and crystalline structures of dipterocarpol were determined by X-ray analysis. Pleiades Publishing, Ltd., 2012.

TRITERPINOIDS FROM MANGIFERA INDICA

Key Word Index - Mangifera indica; Anacardiaceae; triterpinoids. - From the neutral fraction of the n-hexane extract of stem bark of Mangifera indica (var./cv Banganpalli) six new tetracyclic triterpenoids, cycloart-24-ene-3β,26-diol, the C-24 epimers of cycloart-25-ene-3β,24,27-triol, the C-24 epimers of cycloartane-3β,24,25-triol and 3-ketodammar-24E-ene-20S,26-diol together with known compounds cycloartenol, α-amyrin, β-amyrin, sitosterol, 3β-hydroxycycloart-25-en-26-al, dammarenediol II, the C-24 epimers of cycloart-25-ene-3β,24-diol, 24-methylenecycloartane-3β,26-diol, ψ-taraxastane-3β,20-diol and ocotillol II have been isolated.The acidic fraction of the same extract, on esterification with diazomethane followed by chromatography, yielded methyl mangiferonate, methyl isomangiferolate, methyl mangiferolate and diazomethane adduct of methyl mangiferolate.The structures were elucidated by spectroscopic and chemical methods.