19871-39-7

Upstream product

• 36160-52-8 2-ethoxy-4-nitroanisole 
• 74-89-5 methylamine 
• 100-17-4 para-methoxynitrobenzene 
• 149686-06-6 N-(2-methoxyl-5-nitrophenyl)formamide 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 137090-11-0 acetic acid-(N-methyl-o-anisidide) 
• 10541-78-3 2-methoxy-N-methylaniline 
• 636-93-1 5-nitroguaiacol 
• 100200-99-5 potassium 2-methoxy-4-nitrophenolate monohydrate 
• 36160-54-0 2-isopropyloxy-1-methoxy-4-nitrobenzene 
• 455-93-6 2-fluoro-1-methoxy-4-nitrobenzene 
• 709-09-1 3,4-dimethoxynitrobenzene 
• 593-51-1 methylamine hydrochloride 
• 107968-00-3 estrone 4-(2-methoxy-4-nitrophenoxy)butyl ether 

Relevant academic research and scientific papers

Assignment of Quaternary Carbons via Two-Bond Heteronuclear Selective NOE Difference, a Useful Structure Elucidation Aid

Very low power irradiation of suitable narrow peaks in the proton frequency range generated NOE enhancement in neighbouring quaternary carbons, positioned two bonds from the irradiated protons.Subsequent FID acquisition under normal broad band decoupling

Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination

We report both an intermolecular C-H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions.

Arylsulfonanilide ureas

The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,

Arylsulfonanilide derivatives

The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,

THE PHOTOREACTIONS OF 2-FLUORO-4-NITROANISOLE WITH AMINES. THE SEARCH FOR NEW BIOCHEMICAL PHOTOPROBES

The photosubstitutions of 2-fluoro-4-nitroanisole with several amines are studied from the preparative and the preliminary mechanistic points of view.The possible usefulness of this structure as biochemical photoprobe is discussed.

Dynamic Behavior of Photoexcited Solutions of 4-Nitroveratrole Containing OH(1-) or Amines

Kinetics and mechanism of the photoinduced reactions of 4-nitroveratrole (NV) with OH(1-) and a number of aliphatic amines have been studied by laser kinetic spectroscopy and by measurement of transient changes in electrical conductivity.In the case of OH(1-) only reactions with NV in its lowest triplet state (T0) are observed and these lead to substitution of the OCH3 group at atom C(2) of the aromatic molecule and to formation of a number of transient ?-complexes, which return to NV.In the case of the amines both excited singlet state and triplet state reactionsare observed.The singlet state reactions with methylamine and with n-hexylamine lead to substitution of the OCH3 group at atom C(2).Although piperidine quenches the excited singlet states involved, this does not lead to substitution at C(2).The triplet state reactions with the amines start with a discrete electron-transfer reaction in which the radical anion (E) of NV is formed.Subsequent reaction of E with the radical cation of the amine leads to substitution at C(1) and to a number of ?-complexes, which return to NV.

THE SEARCH FOR NEW BIOCHEMICAL PHOTOPROBES. II. THE NUCLEOPHILIC PHOTOSUBSTITUTION OF 2-FLUORO-4-NITROANISOLE.

The photosubstitutions of 2-fluoro-4-nitroanisole with several amines are studied.The preparative results, the thermal stability of the photochemical substrate, and the limiting quantum yield values obtained from photoreactions with several nucleophiles suggest the possible usefulness of 2-fluoro-4-nitrophenyl ethers as biochemical photoprobes.

ON THE REGIOSELECTIVITY OF THE NUCLEOPHILIC AROMATIC PHOTOSUBSTITUTIONS OF 4-NITROVERATROLE. A THREEFOLD MECHANISTIC PATHWAY.

4-Nitroveratrole (NVT) is photosubstituted with primary amines, piperidine and hydroxide ion.Primary amines and hydroxide ion cause replacement of the methoxy group in meta position with respect to the nitro group whereas piperidine photosubstitutes the methoxy group in para to the nitro group.Photoreactions with piperidine and hydroxide ion involve attack of the amine upon a triplet excited state of NVT.Mechanistic evidences indicate that the reaction with hydroxide ion is probably a SN23Ar* process whereas the reaction with piperidine involves a radical ion pair formed via electron transfer from the amine to a triplet excited state.Photoreactions with primary amines involve attack of the amine upon a singlet excited state of NVT (SN21 Ar* process).These results are discussed and justified in the context of nucleophile ionization potential considerations and ground state donor-acceptor complex formation abilities.

4-NITROPYROCATECHOL ETHERS AS POSSIBLE PHOTOAFFINITY LABELS. PHOTOCHEMICAL REACTIONS OF 4-NITROPYROCATECHOL ETHERS OF BIOLOGICALLY ACTIVE COMPOUNDS

The photochemical reactions of O- and N-(2-methoxy-4-nitro)phenoxyalkyl derivatives of estrone and of the antibiotic cycloheximide with methylamine afford clean substitutions of the methoxy group.From these experiments it is inferred that 2-methoxy-4-nitrophenyl ethers can be good photoaffinity labels.

THE NUCLEOPHILIC AROMATIC PHOTOSUBSTITUTION IN PHOTOAFFINITY LABELLING. A MODEL STUDY OF A CYCLOHEXIMIDE DERIVATIVE.

The photoreactions of several 4-nitrocatechol ethers with the relatively hard nucleophile methylamine occurs at the meta position respect to the nitro group.A derivative of the antibiotic cycloheximide carrying a 4-nitrocatechol ether moiety reacts with methylamine affording an in vitro model for photoaffinity labelling.