19920-80-0

Basic information

• Product Name: 1-(4-bromophenyl)cyclohexan-1-ol
• Synonyms: 1-(4-bromophenyl)cyclohexan-1-ol
• CAS NO: 19920-80-0
• Molecular Weight: 255.155
• Mol File: 19920-80-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)cyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)cyclohexan-1-ol(19920-80-0)
• EPA Substance Registry System: 1-(4-bromophenyl)cyclohexan-1-ol(19920-80-0)

Safety Data

• Hazardous Substances Data: 19920-80-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-bromophenyl)cyclohexan-1-ol is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical properties and reactivity. The presence of the bromine atom and the phenyl group allows for a wide range of organic reactions, making it a valuable building block for the development of new drugs and therapeutic agents.
Used in Chemical Industry:
In the chemical industry, 1-(4-bromophenyl)cyclohexan-1-ol is employed as a key intermediate for the production of other organic compounds. Its unique structure and reactivity make it suitable for various applications, including the synthesis of specialty chemicals, dyes, and other industrial products.
Used in Research and Development Laboratories:
1-(4-bromophenyl)cyclohexan-1-ol is utilized in research and development laboratories for the preparation of specialty chemicals. Its unique chemical properties and reactivity make it an essential tool for scientists and researchers working on the development of new chemical processes and products.

Upstream product

• 108-94-1 cyclohexanone 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 106-37-6 1.4-dibromobenzene 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 1605-17-0 1-Bromo-4-(1-cyclohexen-1-yl)benzene 
• 135-70-6 p-quaterphenyl 
• 7295-46-7 1-(4-bromophenyl)-1-hexanone 
• 19920-81-1 2',3',4',5'-tetrahydro-biphenyl-4-carbonitrile 
• 20029-52-1 4-cyclohexylbenzoic acid 
• 19920-83-3 4-cyclohex-1-enyl-benzoic acid 
• 1837-03-2 1,4-di-cyclohex-1-enyl-benzene 
• 74975-97-6 p-(6-acetyl-1-cyclohexenyl)bromobenzene 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 91570-99-9 3-(4-bromophenyl)cyclohex-2-enone 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The present disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

Thioether-linked liquid crystal dimers and trimers: The twist-bend nematic phase

Systematic synthesis of thioether-linked dimers and trimers was carried out to reveal molecular designs for inducing mesophases and twist-bend nematic (NTB) phases. A five-fold approach based on molecular structural parameters including the ter

Flow-Assisted Synthesis of [10]Cycloparaphenylene through Serial Microreactions under Mild Conditions

Cycloparaphenylene (CPP) has been recognized as an attractive template for the bottom-up synthesis of carbon nanotubes with uniform diameter, and is important for the chemistry of graphitic as well as ring-shaped macromolecules. However, the reported rout

Iodine-Promoted Metal-Free Aromatization: Synthesis of Biaryls, Oligo p-Phenylenes and A-Ring Modified Steroids

We describe efficient procedures based on the use of iodine for the synthesis of biaryls from arylcyclohexenols or arylcyclohexanols using sub-stoichiometric/catalytic iodine and dimethyl sulfoxide (DMSO) as oxidant. Heteroarylcyclohexanols also produced the corresponding biaryl products. It was proven that biphenyl can also be efficiently obtained when the quantity of iodine was reduced to 0.05 equiv. The method is compatible with different functional groups in the aromatic ring (either electron-donating or electron-withdrawing groups). For substrate scope, apart from cyclohexanone and cyclohexenone, some substituted cyclohexanones were also used to synthesize the starting arylcyclohexanols. The process was applied to the synthesis of oligo p-phenylenes and A-ring aromatized steroids, where the combined use of I2/DMSO not only provoked the necessary migration of the methyl group at C-10, but also further extended the conjugation.

Enantioselective photoredox catalysis enabled by proton-coupled electron transfer: Development of an asymmetric aza-pinacol cyclization

The first highly enantioselective catalytic protocol for the reductive coupling of ketones and hydrazones is reported. These reactions proceed through neutral ketyl radical intermediates generated via a concerted proton-coupled electron transfer (PCET) event jointly mediated by a chiral phosphoric acid catalyst and the photoredox catalyst Ir(ppy)2(dtbpy)PF6. Remarkably, these neutral ketyl radicals appear to remain H-bonded to the chiral conjugate base of the Bronsted acid during the course of a subsequent C-C bond-forming step, furnishing syn 1,2-amino alcohol derivatives with excellent levels of diastereo- and enantioselectivity. This work provides the first demonstration of the feasibility and potential benefits of concerted PCET activation in asymmetric catalysis.

4-AMINO-5-OXO-7, 8-DIHYDROPYRIMIDO [5,4-F] [1,4] OXAZEPIN-6 (5H) -YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention provides compounds of Formula (I), wherein R1, R2a, R2b, R3, m and A are as defined herein, as well as compositions thereof and methods for treating a disease, condition or disorder that is modulated by the inhibition of the diacylglycerol O-acyltransferase 1 (DGAT-1) enzyme by administering the compounds of the present invention and/or compositions thereof.

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.

PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR

The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.

NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES

The present invention relates to novel benzyl(idene)-lactam derivatives, compounds of the formula (I) wherein R1 is a group of the formula G1 or G2 depicted below, wherein R1, R3, R6, R13, X, a, n and m are as defined herein, their pharmaceutically acceptable salts, and pharmaceutical compositions which include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1B receptors. The compounds of the invention are useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated and have reduced potential for cardiac side effects, in particular QTc prolongation.

Generation of bromophenyllithium reagents from dibromobenzenes and addition to carbonyl and nitrile electrophiles

An evaluation of the mono-lithiation of all three regioisomers of dibromobenzene using n-butylithium was performed. The resulting aryllithium reagents were added to electrophiles such as ketones, aldehydes, nitriles and amides to afford the desired benzylic alcohols or ketones.