199733-96-5

Upstream product

• 14667-47-1 methyl 2-aminonicotinate 
• 603-35-0 triphenylphosphine 
• 199733-97-6 methyl tetrazolo[1,5-a]pyridine-8-carboxylate 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 

Downstream Products

• 199799-14-9 4-(1-Isopropyl-2-oxo-1,2-dihydro-pyridin-3-yl)-1-phenyl-6-[(E)-phenylimino]-5,6-dihydro-1H-[1,3,5]triazin-2-one 
• 199734-01-5 4-Oxo-3-phenyl-2-[(E)-phenylimino]-3,4-dihydro-2H-pyrido[1,2-a][1,3,5]triazine-9-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Reaction between triphenylphosphine and aromatic amines in the presence of diethyl azodicarboxylate: An efficient synthesis of aryliminophosphoranes under neutral and mild conditions

An efficient synthesis of aryliminophosphoranes is described. A mixture of an aromatic amine, diethyl azodicarboxylate and triphenylphosphine undergo a Mitsonobu type reaction at ambient temperature in dry dichloromethane to afford aryliminophosphoranes in excellent yields.

One-pot synthesis of novel (2-Oxo-1,2-dihydropyridin-3-yl)-1,3,5- triazine derivatives from methyl 2-(N- triphenylphosphoranylidene)aminonicotinate, aryl isocyanates and primary amines: Sequential aza-wittig /cycloaddition / ring-transformation reactions

(2-Oxo-1,2-dihydropyridin-3-yl)-1,3,5-triazine derivatives 10 were obtained unexpectedly, in stead of pyrido[2,3-d]pyrimidine derivatives, by the intermolecular aza-Wittig reaction of methyl 2-(N- triphenylphosphoranylidene)aminonicotinate 3 with aryl isocyanates followed by attempted heterocylization by use of prim-amines. A novel sequential aza- Wittig / cycloaddition / ring-transformation mechanism for the formation of 10 has been reported based on the isolation and characterization of the key intermediates, pyrido[1,2-a][1,3,5]triazines 15 formed via [4+2] cycloaddition of the initially produced carbodiimide with aryl isocyanates.