199734-01-5

Upstream product

• 103-71-9 phenyl isocyanate 
• 199733-96-5 N-(3-methoxycarbonyl-2-pyridyl)triphenyliminophosphorane 
• 199733-97-6 methyl tetrazolo[1,5-a]pyridine-8-carboxylate 
• 14667-47-1 methyl 2-aminonicotinate 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 2942-59-8 2-chloronicotinic acid 
• 49609-84-9 2-Chloronicotinoyl chloride 

Relevant academic research and scientific papers

One-pot synthesis of novel (2-Oxo-1,2-dihydropyridin-3-yl)-1,3,5- triazine derivatives from methyl 2-(N- triphenylphosphoranylidene)aminonicotinate, aryl isocyanates and primary amines: Sequential aza-wittig /cycloaddition / ring-transformation reactions

(2-Oxo-1,2-dihydropyridin-3-yl)-1,3,5-triazine derivatives 10 were obtained unexpectedly, in stead of pyrido[2,3-d]pyrimidine derivatives, by the intermolecular aza-Wittig reaction of methyl 2-(N- triphenylphosphoranylidene)aminonicotinate 3 with aryl isocyanates followed by attempted heterocylization by use of prim-amines. A novel sequential aza- Wittig / cycloaddition / ring-transformation mechanism for the formation of 10 has been reported based on the isolation and characterization of the key intermediates, pyrido[1,2-a][1,3,5]triazines 15 formed via [4+2] cycloaddition of the initially produced carbodiimide with aryl isocyanates.