2000-66-0

Basic information

• Product Name: (17α)-Pregn-4-ene-3,20-dione
• Synonyms: (17α)-Pregn-4-ene-3,20-dione;17-Isoprogesterone;17α-Progesterone;Isoprogesterone
• CAS NO: 2000-66-0
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.4617
• Mol File: 2000-66-0.mol

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 447.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (17α)-Pregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (17α)-Pregn-4-ene-3,20-dione(2000-66-0)
• EPA Substance Registry System: (17α)-Pregn-4-ene-3,20-dione(2000-66-0)

Safety Data

• Hazardous Substances Data: 2000-66-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(17α)-Pregn-4-ene-3,20-dione is used as a hormone precursor for the synthesis of testosterone and other sex hormones, which are essential for various physiological functions in the human body. It is particularly important for the development and regulation of the reproductive system.
Used in Diagnostic Applications:
(17α)-Pregn-4-ene-3,20-dione is used as a diagnostic agent in the identification and study of ovarian Leydig cell tumor disease. This condition is characterized by the presence of abnormal cells in the ovaries, and the hormone can help in the detection and monitoring of the disease.

Upstream product

• 103000-97-1 1-(3,20-dioxo-5α-pregnan-2ξ-yl)-pyridinium; bromide 
• 753497-21-1 17β-Δ¹-5β-pregnen-3,20-dione 
• 57968-14-6 Δ¹-5β-pregnen-20-one 
• 1162-54-5 dl-Δ^1,2-pregnadiene-3,20-dione 
• 168609-36-7 3β-acetoxy-14β.17βH-pregnen-(5)-one-(20) 
• 163061-04-9 3β-hydroxy-14β,17α-pregn-5-en-20-one 
• 56-23-5 tetrachloromethane 
• 93-59-4 Perbenzoic acid 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 556-91-2 aluminum tri-tert-butoxide 
• 139527-71-2 20ξ-(Diethylphosphono)-20ξ-isocyano-3-methoxypregna-3,5-diene 
• 64-19-7 acetic acid 
• 17597-24-9 (4β,5)-epoxy-5β-pregnan-3,20-dione 

Downstream Products

• 1051-35-0 C₂₃H₃₄O₃ 
• 7093-55-2 C₂₅H₃₈O₄ 
• 57-83-0 Progesterone 
• 115758-64-0 15α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione 
• 24377-08-0 Pregna-4,14-diene-3,20-dione 
• 7755-32-0 5α-pregnane-3,15,20-trione 
• 5508-55-4 (+)-21-hydroxy-3,20-dioxo-pregna-1,4-diene 
• 1096-38-4 16-dehydroprogesterone 
• 104396-80-7 11α-benzoyloxyprogesterone 
• 564-63-6 14-hydroxy-4-androstene-3,17-dione 
• 516-15-4 11-Ketoprogesterone 
• 122723-77-7 Benzoic acid 17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl ester 
• 98774-50-6 3-benzylthiopregna-3,5-dien-20-one 
• 7093-55-2 5-pregnene-3,20-dione-3,20-bisethyleneketal 

Relevant articles and documents

Alternative synthetic approaches to rac-progesterone by way of the classic Johnson cationic polycyclization strategy

Three alternative synthetic entries into Johnson's classic synthesis of rac-progesterone are presented in this manuscript. ent-Progesterone, the non-natural enantiomer of progesterone, has recently been identified as a potential alternative to progesterone for investigations into possible prevention and treatment of traumatic brain injury (TBI). Difficulties in accessing ent-progesterone in large quantities prevent it from being studied more thoroughly. Strategies for producing synthetic rac-progesterone are described and discussed herein.

Direct Formation of the Steroid Nucleus by a Biomimetic Cyclization

The aim of this study was to synthesize the trienynol 3 and to study its cyclization.The substrate was synthesized by a convergent route, the key step being the stereoselective Wittig-Schlosser condensation of the known aldehyde 19 with the phosphorane 18

Structural requirements for progestational activity. Synthesis and properties of rac-8α,9β,10α,14β-progesterone

rac-8α,9β,10α,14β-progesterone, 1, has been synthesized and subjected to X-ray crystallographic analysis which established that the ring conformations are A, 1β-sofa; B, chair; C, chair; and D, intermediate between an envelope and a half-chair. This compound is 10% as active as progesterone in the Clauberg assay and has an affinity for the uterine cytosol (rabbit) receptor for progesterone 2% as great as that of progesterone.