20009-27-2Relevant academic research and scientific papers
Exploiting ancillary ligation to enable nickel-catalyzed c-o cross-couplings of aryl electrophiles with aliphatic alcohols
MacQueen, Preston M.,Tassone, Joseph P.,Diaz, Carlos,Stradiotto, Mark
supporting information, p. 5023 - 5027 (2018/04/24)
The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos) enables the C(sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcohols with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp2)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.
Microwave-Assisted solid-liquid phase alkylation of naphthols
Balint, Erika,Kovacs, Orsolya,Drahos, Laszlo,Keglevich, Gyoergy
, p. 330 - 336 (2013/07/26)
The microwave promoted alkylation of 1- and 2-naphthols with benzyl, butyl, ethyl and isopropyl halides in the presence of an alkali carbonate may result in O- and C-Alkylated products. The alkylations were O-selective in the presence of K2CO3 in acetonitrile as the solvent and in the absence of phase transfer catalyst. The alkylations utilizing butyl and ethyl halides were also O-selective in solventless accomplishment and in the presence of triethylbenzylammonium chloride.
One-pot synthesis of 4-alkoxybenzo[c]thiophenes
Akbarzadeh, Tahmineh,Shafiee, Abbas
, p. 1455 - 1462 (2007/10/03)
The reaction of N-bromosuccinimide with 4,5,6,7-tetrahydrobenzo[c]thiophen-4-ones in the presence of 2,2′-azo-bis-isobutyronitrile followed by heating under reflux with different alcohols produces 4-alkoxybenzo[c]thiophenes in good yield.
