20029-52-1

Basic information

• Product Name: 4-CYCLOHEXYLBENZOIC ACID
• Synonyms: 4-CYCLOHEXYLBENZOIC ACID;P-CYCLOHEXYLBENZOIC ACID;Cyclohexybenzoicacid;4-CYCLOHEXYLBENZOIC ACID 98+%;Cyclohexyl benzoic acid;(4-Carboxyphenyl)cyclohexane
• CAS NO: 20029-52-1
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.26
• EINECS: 243-472-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 20029-52-1.mol

Chemical Properties

• Melting Point: 200°C
• Boiling Point: 351.1 °C at 760 mmHg
• Flash Point: 163.9 °C
• Appearance: /
• Density: 1.115 g/cm³
• Vapor Pressure: 1.56E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1966671
• CAS DataBase Reference: 4-CYCLOHEXYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOHEXYLBENZOIC ACID(20029-52-1)
• EPA Substance Registry System: 4-CYCLOHEXYLBENZOIC ACID(20029-52-1)

Safety Data

• Statements: 36/37/38-52/53
• Safety Statements: 26-36/37/39-61-37
• Hazardous Substances Data: 20029-52-1(Hazardous Substances Data)

Usage

Chemical Properties

Solid

InChI:InChI=1/C13H16O2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h6-10H,1-5H2,(H,14,15)/p-1

Upstream product

• 27634-89-5 4-cyclohexylbenzaldehyde 
• 18594-05-3 4-cyclohexylacetophenone 
• 27634-88-4 4-cyclohexyl-1-cyanobenzene 
• 208259-47-6 4-cyclohexylphenylmethyl alcohol 
• 110-82-7 cyclohexane 
• 94-36-0 dibenzoyl peroxide 
• 19920-83-3 4-cyclohex-1-enyl-benzoic acid 
• 4501-36-4 1-cyclohexyl-4-methylbenzene 
• 92-92-2 biphenyl-4-carboxylic acid 
• 4463-31-4 4-cyclohexylbenzyl chloride 
• 7732-18-5 water 
• 124-38-9 carbon dioxide 
• 7697-37-2 nitric acid 
• 60-29-7 diethyl ether 

Downstream Products

• 959141-01-6 4-cyclohexyl-benzoic acid ethyl ester 
• 121193-16-6 4-cyclohexyl-benzoyl chloride 
• 92863-34-8 4-cyclohexylbenzoic acid methyl ester 
• 89326-63-6 C₂₆H₃₀O₃ 
• 3488-45-7 2-<4-Cyclohexyl-phenyl>-2-oxo-diazoaethan 
• 905308-71-6 3-(4-bromo-2-methyl-phenyl)-5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazole 
• 905308-51-2 4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-benzoic acid methyl ester 
• 905308-53-4 {4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-phenyl}-acetic acid ethyl ester 
• 911450-38-9 3-{4-[5-(4-cyclohexyl-phenyl)-[1,2,4]oxadiazol-3-yl]-3-methyl-phenyl}-propionic acid methyl ester 
• 1028947-21-8 C₂₅H₃₄N₂O₃Si 
• 635701-91-6 4-(5-(4-cyclohexylphenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde 

Relevant articles and documents

Preparation method of 4-cyclohexylbenzoic acid

The invention relates to the technical field of medicine preparation, in particular to a preparation method of 4-cyclohexylbenzoic acid. The preparation method comprises the following steps: 1) preparing a Grignard reagent from 1-bromo-4-cyclohexylbenzene; 2) subjecting the Grignard reagent to reacting with carbon dioxide in an organic solvent; and 3) carrying out acidifying to obtain the 4-cyclohexylbenzoic acid. According to the preparation method of the 4-cyclohexylbenzoic acid, the raw materials are easy to obtain, cost is low, a process is stable, and the prepared 4-cyclohexylbenzoic acid is high in chemical purity; and the conditions of heating, usage of magnesium powder and the like are creatively designed, a small amount of bromocyclohexyl benzene is firstly added for initiation, and then residual bromobenzene is added under the condition of heating, so the preparation of the Grignard reagent of 1-bromo-4-cyclohexylbenzene is realized, the technical defect that an expensive catalyst or an expensive ligand needs to be adopted for preparing 4-cyclohexylbenzoic acid in the prior art is overcome, and remarkable progress is achieved.

Iodine-catalyzed oxidative C-C bond cleavage for benzoic acids and benzamides from alkyl aryl ketones

Iodine-catalyzed oxidative C-C bond cleavage has been performed for the facile synthesis of both benzoic acids and benzamides from readily available alkyl aryl ketones. Additionally benzylidene acetones and phenylacetylenes were also converted to the corresponding aromatic acids under the same conditions. This approach features the use of inexpensive iodine as a catalyst, broad substrate scope and open air conditions.

Copper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: A facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids

A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and methyl to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.

PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.

Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes

A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.

Pincer thioamide and pincer thioimide palladium complexes catalyze highly efficient negishi coupling of primary and secondary alkyl zinc reagents at room temperature

Pincer thioamide PdII complex 2 was prepared, and its reaction with cyclohexylzinc chloride yielded novel pincer thioimide PdII complex 3 besides Pd0 species. The structures of complexes 2 and 3 were confirmed by X-ray ana

Synthesis of aromatic carboxylic acids by carbonylation of aryl halides in the presence of epoxide-modified cobalt carbonyls as catalysts

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in a high yield under very mild conditions. Highly active catalytic systems, base-containing alcoholic solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides. 2005 Pleiades Publishing, Inc.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P1) receptor agonists with minimal affinity for the S1P2 and S1P3 receptor subtypes. Analogue 26 (S1P1 IC50 = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P3 receptor agonism is not a component of immunosuppressive efficacy.

INHIBITORS OF FUNGAL INVASION

This invention relates to various anti-fungall agents including agents that are inhibitors of fungal invasion.

SYNTHESIS OF POLYCARBOXYLIC ACIDS OF BIPHENYL. II. OXIDATION OF CYCLOHEXYLTOLUENES AND METHYLBIPHENYLS TO CARBOXYLIC ACIDS

During the liquid-phase catalytic oxidation of cyclohexyltoluenes and methylbiphenyls in the presence of a cobalt catalyst the methyl group exhibits high reactivity, and it increases in the series of ortho, meta, and para isomers. The minimal reactivity of the methyl group at the ortho position is explained by steric factors.