200435-09-2

Upstream product

• 622-32-2 (Z)-benzaldehyde oxime 
• 70288-60-7 methyl 2-bromo-3-phenylpropionate 
• 100-39-0 benzyl bromide 
• 79751-42-1 (Benzylidenamino)ethansaeure-methylester-N-oxid 
• 200435-16-1 benzylamino-3-phenylpropionic acid methyl ester 

Downstream Products

• 68844-60-0 2-(5-oxo-3,4-diphenyl-[1,2,4]oxadiazolidin-2-yl)-3-phenyl-propionic acid methyl ester 
• 68844-62-2 (5RS)-2-((Ξ)-1-methoxycarbonyl-2-phenyl-ethyl)-3c-phenyl-isoxazolidine-5r-carboxylic acid methyl ester 
• 68844-62-2 (5RS)-2-((Ξ)-1-methoxycarbonyl-2-phenyl-ethyl)-3t-phenyl-isoxazolidine-5r-carboxylic acid methyl ester 
• 21209-63-2 2-(Hydroxyamino)-3-phenylpropansaeure-methylester 

Relevant academic research and scientific papers

Inhibition of thermolysin with nitrone-bearing substrate analogs: A new type of thermolysin inhibitors

Nitrones are utilized as the active site zinc coordinating functionality in the design ofinhibitors for thermolysin. This new type of thermolysin inhibitors are as potent as the existing inhibitors bearing a carboxylate or hydroxamate zinc ligating moiety.

Synthesis of N-Hydroxy-α-amino Acids by Alkylation of N-Benzylidene-α-amino Acid Methyl Ester N-oxides

The higher N-benzylidene-α-amino acid methyl ester N-oxides 3c-t were obtained from the lower nitrone esters 3a and b by base induced alkylation in α-position of the N->O-group.The compounds 3 were converted into the N-hydroxy-α-amino acid methyl esters 6 by heating with hydroxylamine hydrochloride in ethanol and into N-hydroxy-α-amino acids 7 with concd. hydrochloric acid. - Compound 3d was, on heating in toluene, converted to methyl 1-aza-7-oxabicycloheptanecarboxylate 8 by intramolecular cycloaddition.