Inhibition of thermolysin with nitrone-bearing substrate analogs: A new type of thermolysin inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00023-7

Nitrones are utilized as the active site zinc coordinating functionality in the design ofinhibitors for thermolysin. This new type of thermolysin inhibitors are as potent as the existing inhibitors bearing a carboxylate or hydroxamate zinc ligating moiety.