20069-27-6Relevant academic research and scientific papers
In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) c
Kovala-Demertzi, Dimitra,Papageorgiou, Athanassios,Papathanasis, Leuteris,Alexandratos, Alexandros,Dalezis, Panagiotis,Miller, John R.,Demertzis, Mavroudis A.
, p. 1296 - 1302 (2009)
Reactions of thiosemicarbazones of 2-formyl and 2-acetyl pyridine and containing an azepane ring (hexamethyleneiminyl ring) incorporated at N(4)-position, HL1 (1) and HL2 (2) with platinum(II) afforded the complexes, [Pt(L1/sup
Structural and spectral studies of an iron(III) complex [Fe(Pranthas) 2][FeCl4] derived from 2-acetylpyridine-N(4), N(4)-(butane-1, 4-diyl) thiosemicarbazone (HPranthas)
Sreekanth,Fun, Hoong-Kun,Prathapachandra Kurup
, p. 61 - 67 (2005)
A novel iron(III) complex of 2-acetylpyridine N(4), N(4)-(butyl-1, 4-diyl) thiosemicarbazone (HPranthas), [Fe(Pranthas)2]FeCl4 was synthesized and physico-chemically characterized by means of partial elemental analysis, magnetic meas
2-Pyridineformamide N(4)-ring incorporated thiosemicarbazones inhibit MCF-7 cells by inhibiting JNK pathway
Shakya, Bhushan,Shahi, Nerina,Ahmad, Faiz,Yadav, Paras Nath,Pokharel, Yub Raj
, p. 1677 - 1681 (2019)
In an effort to develop a more potent anticancer therapeutic agent, a series of 2-pyridineformamide thiosemicarbazones (R = H, 4-CH3, 5-F, 6-CH3 and (Figure presented.)(Figure presented.))have been synthesized and evaluated for their
Synthesis and characterization studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of carboxymethyl-N-methyl-N-phenyl dithiocarbamate
Kumar, Lekshmi V.,Rathika Nath
, p. 3064 - 3069 (2018)
Complexes of carboxymethyl-N-methyl-N-phenyl dithiocarbamate (DTC) with cobalt(II), nickel((II), copper(II) and zinc(II) complexes were synthesized in 1:2 molar ratio with general formula [M(DTC)2],{M=Co(II)/Ni(II)/Cu(II)/Zn(II)} and characteri
Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone
Kumar, Lekshmi V,Nath, G Rathika
, (2019)
Abstract: Complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone with cobalt(II), nickel((II), copper(II) and zinc(II) metal ions were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, infrared spectra, electron
Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents
Shakya, Bhushan,Yadav, Paras Nath,Ueda, Jun-Ya,Awale, Suresh
supporting information, p. 458 - 461 (2014/01/23)
Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thios
Imaging intracellular zinc by using a glyoxal bis(4-methyl-4-phenyl-3- thiosemicarbazone) ligand
Palanimuthu, Duraippandi,Shinde, Sridevi Vijay,Dayal, Disha,Somasundaram, Kumaravel,Samuelson, Ashoka G.
supporting information, p. 3542 - 3549 (2013/07/26)
The ligand glyoxal bis(4-methyl-4-phenyl-3-thiosemicarbazone) (GTSCH 2) is shown to be a selective fluorescence "turn-on" sensor for zinc ions (Zn2+). This sensor is easy to synthesize, exhibits excellent sensitivity and selectivity
Novel second-generation Di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo
Lovejoy, David B.,Sharp, Danae M.,Seebacher, Nicole,Obeidy, Peyman,Prichard, Thomas,Stefani, Christian,Basha, Maram T.,Sharpe, Philip C.,Jansson, Patric J.,Kalinowski, Danuta S.,Bernhardt, Paul V.,Richardson, Des R.
, p. 7230 - 7244 (2012/11/13)
We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT) and 2-benzoylpyr-idine thiosemicarbazone (BpT) ligands to improve the efficacy and safety profile of these potential antitumor agents. Two novel DpT analogues, Dp4e4mT and DpC, exhibited pronounced and selective activity against human lung cancer xenografts in vivo via the intravenous and oral routes. Importantly, these analogues did not induce the cardiotoxicity observed at high nonoptimal doses of the first-generation DpT analogue, Dp44mT. The Cu(II) complexes of these ligands exhibited potent antiproliferative activity having redox potentials in a range accessible to biological reductants. The activity of the copper complexes of Dp4e4mT and DpC against lung cancer cells was synergistic in combination with gemcitabine or cisplatin. It was demonstrated by EPR spectroscopy that dimeric copper compounds of the type [CuLCl]2, identified crystallographically, dissociate in solution to give monomeric 1:1 Cu:ligand complexes. These monomers represent the biologically active form of the complex.
