271247-34-8Relevant articles and documents
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase
Tamayo, Nuria,Liao, Lillian,Goldberg, Martin,Powers, David,Tudor, Yan-Yan,Yu, Violeta,Wong, Lu Min,Henkle, Bradley,Middleton, Scot,Syed, Rashid,Harvey, Timothy,Jang, Graham,Hungate, Randall,Dominguez, Celia
, p. 2409 - 2413 (2007/10/03)
Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition o