20151-37-5

Upstream product

• 108-89-4 picoline 
• 100-52-7 benzaldehyde 
• 6844-47-9 4-[(trimethylsilanyl)methyl]-pyridine 
• 10445-91-7 4-(Chloromethyl)pyridine 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 98-88-4 benzoyl chloride 
• 1620-55-9 1-phenyl-2-(4-pyridinyl)ethanone 

Downstream Products

• 108-89-4 picoline 
• 5097-93-8 trans-4-styrylpyride 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Unexpected crystallization and X-ray crystal structure of racemic 1-phenyl-2-(4-pyridyl)ethanol intermediate

We have isolated, by crystallization, the intermediate, 1-phenyl-2-(4-pyridyl)ethanol, from the condensation reaction of 4-methylpyridine with benzaldehyde in which the aim was to obtain the model compound 4-styrylpyridine in absence of a condensing agent

Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes

The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of α-heterocyclic acetophenone derivatives is reported. Products of up to 99% ee were formed.

1,2-Diarylethanols by alternative regioselective reductive ring-opening of 2,3-diaryloxiranes

Non-symmetrical ￡rans-2,3-diaryloxiranes have been regioselectively opened by catalytic hydrogenation over Pd/C, NaBH4/Pd and [Cp 2TiCl]/H2O. Although in the catalytic hydrogenation reactions the epoxides were mainly opened at the β-carbon with respect to the substituted aryl ring in all cases, with the [Cp2TiCl]/H 2O system the regioselectivity was affected by the electronic properties of the aryl residues, the epoxides being opened on the carbon bearing the most electron-releasing or the least electron-withdrawing group. With the NaBH4/Pd system different regioisomers were obtained depending on the substituents. Starting from enantioenriched epoxides, no loss of optical purity was observed in the alcohols formed.

Electrophilic reaction of N-Lewis acid and N-oxide Lewis acid complexes of 4-methylpyridines and their N-oxides through base-induced deprotonation

The comparative studies were carried out on the relative reactivity of4-methylpyridines, their N-oxides and their Lewis acid complexes towards electrophilic reaction. α-Deprotonation in pyridine ring rather than deprotonation of active methyl group or metal-halogen exchange occurred preferentially in the reaction of N- and N-oxides BF3 complexes with electrophile in the presence of LTMP-TMEDA in THF to give a -substituted-4-methylpyridines and their N-oxides.

Cation sensors containing a (bpy)Re(CO)3 group linked to an azacrown ether via an alkenyl or alkynyl spacer: Synthesis, characterisation, and complexation with metal cations in solution

Two [(bpy)Re(CO)3L]+ complexes (bpy = 2,2′-bipyridine), where L contains an aza-15-crown-5 ether which is linked to Re via an alkenyl- or alkynyl-pyridine spacer, have been synthesised along with model complexes. Solutions of the com

Silver catalyzed zinc Barbier reaction of benzylic halides in water

Benzylic chlorides react in aqueous dibasic potassium phosphate under silver catalysis with aromatic aldehydes in the presence of zinc dust to give 1,2-diaryl alcohols in moderate to good yields. Dimerization to bibenzyls and reduction of the halide are important side reactions. A wide range of substituted aromatic and heteroaromatic aldehydes and of substituted benzylic chlorides can be used. Aliphatic aldehydes and ketones are unreactive. A mechanism of two SET on the metal surface is discussed.

Lewis Acid Complexed Heteroatom Carbanions; Synthesis of some α-Pyridyl Alcohols

Metallation of BF3-pyridine complex with lithium tetramethylpiperidide (LTMP) in ether at -78 deg C, followed by reaction with carbonyl compounds, affords α-pyridyl alcohols in good yields.

STEREO- AND REGIO-SELECTIVE ALDOL-TYPE REACTIONS OF ALKYLPYRIDINES WITH BENZALDEHYDE

Stereo- and regio-selectivity in the reaction of alkylpyridines with benzaldehyde were studied.Erythro-selectivity could be obtained in the reaction of 2-alkylpyridine with benzaldehyde in the presence of dialkylboryl triflate and triethylamine.Substituti

FLUORIDE ION INDUCED REACTIONS OF ORGANOSILANES WITH ELECTROPHILES

Benzyl- 4-picolyl- and phenylallyl(trimethyl)silanes react with electrophiles in the presence of KF/18-crown-6 or silica-TBAF under mild conditions.