201603-51-2

Upstream product

• 35958-64-6 3,5,6-Tri-O-benzyl-D-glucofuranose 
• 100-39-0 benzyl bromide 
• 55902-93-7 methyl 3,5,6-tri-O-benzyl-α,β-D-glucofuranoside 

Downstream Products

• 195304-51-9 (1R,2R)-1,2-Bis-benzyloxy-1-[(R)-4-((R)-1,2-bis-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-9-phenyl-nonan-3-one 
• 195304-52-0 (1S,5R,6R,7R)-6,7-Bis-benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-1-(6-phenyl-hexyl)-2,8-dioxa-bicyclo[3.2.1]octane 
• 195304-46-2 {(2S,3R)-2,3-Bis-benzyloxy-3-[(R)-4-((R)-1,2-bis-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propoxy}-tert-butyl-dimethyl-silane 
• 195304-44-0 (3R,4R,5S)-4,5-Bis-benzyloxy-3-((R)-1,2-bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hex-1-en-3-ol 
• 195304-45-1 (3R,4R,5S)-4,5-Bis-benzyloxy-3-((R)-1,2-bis-benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-hexane-1,3-diol 
• 195304-43-9 (2R,4R,5S)-1,2,4,5-Tetrakis-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-hexan-3-one 
• 195304-42-8 (2R,3R,4S,5S)-1,2,4,5-Tetrakis-benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-hexan-3-ol 
• 195304-48-4 (2R,3R)-2,3-Bis-benzyloxy-3-[(R)-4-((R)-1,2-bis-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propionaldehyde 
• 195304-47-3 (2S,3R)-2,3-Bis-benzyloxy-3-[(R)-4-((R)-1,2-bis-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propan-1-ol 
• 195304-41-7 (2S,3S,4R,5R)-2,3,5,6-Tetrakis-benzyloxy-hexane-1,4-diol 
• 195304-53-1 (1S,5R,6R,7R)-5-((R)-1,2-Dihydroxy-ethyl)-1-(6-phenyl-hexyl)-2,8-dioxa-bicyclo[3.2.1]octane-6,7-diol 
• 851178-82-0 C₄₁H₄₈O₅S₂ 

Relevant academic research and scientific papers

Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3,4-unsubstituted derivative

Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.

Compound and preparation method and application thereof

The invention provides a compound shown in the formula I and a preparation method thereof and a method for detecting Gliflozin medicine through high performance liquid chromatography. According to the preparation method, 3,5,6-tribenzyl-D-glucofuranose serves as a raw material, a methylation reaction, a benzyl substitution reaction, demethylating and ketalation are carried out, 3,5,6-tribenzyl-D-glucofuranose and a halide intermediate are subjected to a nucleophilic addition, the material makes contact with triethyl silicane and boron trifluoride diethyl etherate, finally, the material makes contact with ethanethiol and boron trifluoride diethyl etherate, and the target impurity product can be obtained. By means of the method, directional preparation is achieved for synthesis of the target product; the target product provides a reliable impurity reference substance for quality research and impurity quantitative control of industrially-produced Gliflozin series diabetes treatment medicine products. The formula I is shown in the specification.