38102-67-9

Usage

InChI:InChI=1/C11H12O4/c1-15-9-4-2-3-8(7-9)10(12)5-6-11(13)14/h2-4,7H,5-6H2,1H3,(H,13,14)

Upstream product

• 1115-30-6 diethyl acetylsuccinate 
• 2051-95-8 succinylbenzene 
• 108-30-5 succinic acid anhydride 
• 100-66-3 methoxybenzene 
• 105-36-2 ethyl bromoacetate 
• 6328-00-3 4-(3-nitro-phenyl)-4-oxo-butyric acid 
• 1711-05-3 m-anisoyl chloride 
• 56872-07-2 4-(3-hydroxy-phenyl)-4-oxo-butyric acid 
• 77-78-1 dimethyl sulfate 
• 38102-72-6 4-oxo-4-(3-methoxyphenyl)butanenitrile 

Downstream Products

• 38102-79-3 (+)-(R)-γ-(3-methoxyphenyl)-γ-butyrolactone 
• 20175-97-7 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime 
• 6836-19-7 7-Methoxy-1-tetralone 
• 1427435-39-9 7-(4-methoxyphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-thione 
• 1427435-38-8 7-(4-methoxyphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-one 
• 1445852-90-3 C₁₂H₁₄N₂O₃ 
• 1427435-37-7 7-(4-methoxyphenyl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine 
• 1017-06-7 6-(4-Methoxyphenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 1283458-79-6 C₁₇H₁₇NO₃ 
• 38102-68-0 rac-5-(3-methoxyphenyl)dihydrofuran-2(3H)-one 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 692728-90-8 4-(4-fluoro-benzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one 

Relevant academic research and scientific papers

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives

Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3, 5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs.

THIOTRIAZOLYL DERIVATIVES

The invention relates to KvI.5 ion channel antagonists. Novel thiotriazolyl derivative compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by KvI.5 ion channels, are disclosed. Such cond