24743-11-1

Basic information

• Product Name: 4-(3-methoxyphenyl)butanoic acid
• Synonyms: 3-Methoxybenzenebutanoic acid;4-(3-Methoxyphenyl)butanoic acid;Benzenebutanoic acid, 3-methoxy-;4-(3-Methoxy-phenyl)-butyric acid
• CAS NO: 24743-11-1
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.2271
• Mol File: 24743-11-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 129.1°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 5.09E-05mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: 4-(3-methoxyphenyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methoxyphenyl)butanoic acid(24743-11-1)
• EPA Substance Registry System: 4-(3-methoxyphenyl)butanoic acid(24743-11-1)

Safety Data

• Hazardous Substances Data: 24743-11-1(Hazardous Substances Data)

Usage

General Description

4-(3-methoxyphenyl)butanoic acid, also known as GABA, is a chemical compound that has been studied for its potential medicinal properties. It is a derivative of butyric acid and contains a 3-methoxyphenyl group. GABA has been investigated for its potential as a GABA receptor agonist, which could have implications for its use in the treatment of neurological disorders. Additionally, GABA has been studied for its potential as an anti-inflammatory and anti-cancer agent. It is important to note that further research is needed to fully understand the potential therapeutic applications of 4-(3-methoxyphenyl)butanoic acid.

InChI:InChI=1/C11H14O3/c1-14-10-6-2-4-9(8-10)5-3-7-11(12)13/h2,4,6,8H,3,5,7H2,1H3,(H,12,13)

Upstream product

• 91152-85-1 3-(3'-methoxyphenyl)-1-butyronitrile 
• 2398-37-0 3-methoxyphenyl bromide 
• 625-38-7 but-3-enoic acid 
• 10365-98-7 3-methoxyphenylboronic acid 
• 24743-14-4 1-allyl-3-methoxybenzene 
• 100-66-3 methoxybenzene 
• 1798-09-0 m-methoxyphenylacetic acid 
• 18904-42-2 4-(m-Methoxy-phenyl)-Δ³-butensaeure-ethylester 
• 194932-65-5 C₁₃H₁₆O₃ 
• 65292-99-1 2-(3-methoxyphenyl)acetaldehyde 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 603-35-0 triphenylphosphine 
• 137744-81-1 (E)-4-(m-methoxyphenyl)but-3-enoic acid 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 57816-01-0 ethyl 4-(3'-methoxyphenyl)butyrate 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 22245-89-2 7-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 436155-55-4 methyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate 
• 436155-56-5 phenyl 2-[4-(3-methoxyphenyl)butanoyl]hydrazinecarboxylate 
• 436155-78-1 phenyl (7-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)carbamate 
• 24743-09-7 8-(3-methoxy-phenyl)-5-oxo-octanoic acid 
• 6836-19-7 7-Methoxy-1-tetralone 
• 20175-97-7 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime 
• 1610999-42-2 3-[4-(4-phenylpiperazin-1-yl)butyl]phenol 
• 1610999-41-1 1-[4-(3-methoxyphenyl)butyl]-4-phenylpiperazine 
• 1610999-39-7 4-(3-methoxyphenyl)-1-(4-phenylpiperazin-1-yl)butan-1-one 
• 77259-96-2 5-Brom-8-methoxy-1,2,3,4-tetrahydro-1-naphthalinon 
• 6321-53-5 2-[2-(3-methoxyphenyl)ethyl]cyclohexane-1,3-dione 

Relevant articles and documents

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Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides

Liquid-assisted grinding has been successfully applied to eliminate the requirements of chemical activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mechanical ones,e.g.the rotational speed of mill, the filling degree of jar and ball size, have been found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mechanical parameters led to an optimal condition under which a variety ofn-alky aromatics with various functional groups could be readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling has been demonstrated in the gram-scale synthesis of 6-methoxytetralone.

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.