20220-77-3

Upstream product

• 1226-64-8 1,3-bis-(2-methoxy-phenyl)-thiourea 
• 248279-10-9 N,N'-bis-(2-methoxy-phenyl)-S-methyl-isothiourea 
• 700-87-8 1-Isocyanato-2-methoxy-benzene 
• 75-15-0 carbon disulfide 
• 56704-84-8 2-methoxy-N-(triphenylphosphoranylidene)aniline 
• 90-04-0 2-methoxy-phenylamine 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 

Downstream Products

• 84575-27-9 7-methoxy-1H-indole-2,3-dione 
• 85442-67-7 2-(1,4-Diphenyl-6-thioxo-1,6-dihydro-[1,3,5]triazin-2-yl)-1,3-bis-(2-methoxy-phenyl)-isothiourea; hydrochloride 
• 85442-69-9 1,3-Bis-(2-methoxy-phenyl)-2-(4-phenyl-6-thioxo-1-p-tolyl-1,6-dihydro-[1,3,5]triazin-2-yl)-isothiourea; hydrochloride 
• 85442-68-8 1,3-Bis-(2-methoxy-phenyl)-2-(4-phenyl-6-thioxo-1-o-tolyl-1,6-dihydro-[1,3,5]triazin-2-yl)-isothiourea; hydrochloride 
• 1226-63-7 1,3-bis(2-methoxyphenyl)urea 

Relevant academic research and scientific papers

A facile method for the preparation of carbodiimides from thioureas and (Boc)2O

A concise method for the preparation of carbodiimides from thioureas using di-tert-butyl dicarbonate [(Boc)2O] as the dehydrosulfurizative reagent has been developed. Using DMAP as the catalyst, a variety of symmetric and asymmetric 1,3-diaryl thioureas were converted into the corresponding carbodiimides efficiently in a short time.

O-Iodoxybenzoic acid mediated oxidative desulfurization of 1,3-disubstituted thioureas to carbodiimides

An efficient and mild oxidative desulfurization procedure using o-iodoxybenzoic acid has been developed for the synthesis of carbodiimides starting from easily synthesizable 1,3-disubstituted thioureas.

A greener synthetic protocol for the preparation of carbodiimide

A new and facile preparation of symmetrical and unsymmetrical 1,3-diaryl and aryl-alkyl carbodiimides via a dehydrosulfurisation of their corresponding thioureas is described. Herein, the classical method of oxidative desulfurisation of thiourea to carbodiimide involving toxic heavy metal oxides (HgO) has been replaced with an easily available, cost-effective and environmentally benign reagent, iodine. Simple reaction conditions, easy purification of the products and high yields are important attributes of the present methodology and perhaps the best alternative from a green chemistry perspective. The only limitation to this method however, is in the preparation of 1,3-dialkyl substituted carbodiimide.

Hypervalent iodine(III)-mediated regioselective N-acylation of 1,3-disubstituted thioureas

(Chemical Equation Presented) Reaction of asymmetrical 1,3-disubstituted thioureas with diacetoxyiodobenzene (DIB) produces regioselectively N-acetylurea in shorter time. Regioselectivity is dependent on the pKa's of the amine attached to the t