203259-18-1

Upstream product

• 100-39-0 benzyl bromide 
• 55020-67-2 1,2-bis-benzyloxy-3-methoxy-benzene 
• 203259-12-5 C₂₁H₂₁BO₅ 
• 203259-23-8 2,3-dibenzyloxy-4-methoxy-1-bromobenzene 
• 61559-82-8 1-Bromo-2,3dihydroxy-4methoxy-benzene 
• 934-00-9 3-methocycatechol 
• 203259-13-6 (2S,3S)-1-Benzoyl-4-(2,3-bis-benzyloxy-4-methoxy-phenyl)-3-tert-butoxycarbonylmethyl-2,3-dihydro-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 86630-09-3 Acromelic acid A 

Relevant academic research and scientific papers

A biomimetic approach to the pyridone rings of the acromelic acids: A concise synthesis of acromelic acid a and an approach to acromelic acid B.

The syntheses of acromelic acid A 1, allo-acromelic acid A 19 and an approach towards acromelic acid B 2 are described. Palladium (0) catalysed cross-coupling reactions were used to generate C-4 catechol precursors and formation of the pyridone rings was investigated using a biomimetic oxidative cleavage - recyclisation strategy.

Concise syntheses of acromelic acid A and allo-acromelic acid A

Acromelic acid A 1 and allo-acromelic acid A 12 were synthesised in a biomimetic fashion. An oxidative cleavage-recyclisation strategy was used to construct the requisite C-4 pyridone from an intermediate catechol.