203806-77-3Relevant articles and documents
Application of the asymmetric aminohydroxylation reaction for the syntheses of HIV-protease inhibitor, hydroxyethylene dipeptide isostere and γ-amino acid derivative
Kondekar, Nagendra B.,Kandula, Subba Rao V.,Kumar, Pradeep
, p. 5477 - 5479 (2007/10/03)
An enantioselective synthesis of lactone 1, a precursor to the (2R,4S,5S) hydroxyethylene dipeptide isostere and amino acid AHPPA 2 has been accomplished from the common intermediate 5 employing Sharpless asymmetric aminohydroxylation as the key step.
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase
Yuan,Munoz,Wong,Haeggstrom,Wetterholm,Samuelsson
, p. 211 - 220 (2007/10/02)
Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh